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Description
"Diamine Oxidase (DAO)" is a supplement containing an enzyme responsible for breaking down histamine in the digestive system. Naturally produced in the kidneys, thymus, and gastrointestinal lining, DAO plays a role in metabolizing dietary histamine to maintain balance. This supplement is frequently included in protocols for individuals managing histamine sensitivity, helping to address related digestive and systemic responses. Recognized for its enzymatic activity, DAO remains an essential component in targeted nutritional support for histamine metabolism.
Category
Enzymes
When To Take It
DAO is best taken before meals to help break down histamine in food, improving digestive comfort for those with histamine sensitivity.
Synergy and Antagonism
Diamine oxidase (DAO) activity may be supported by vitamin B6, as it plays a role in histamine metabolism. No clear antagonistic interactions have been documented.
Diamine oxidase (DAO) activity may be supported by vitamin B6, as it plays a role in histamine metabolism. No clear antagonistic interactions have been documented.

Diamine Oxidase
May Help With The Following Conditions
At present, there is no established association between this supplement and any medical condition listed on the Health Status pages.
Warnings
DAO supplements are generally considered safe with minimal side effects reported. However, individuals with severe histamine intolerance or underlying digestive conditions should consult a healthcare professional before use.