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Description
"Alpha-Lipoic Acid (ALA)" is a supplement derived from both dietary sources and endogenous production, classified as a fat- and water-soluble compound with antioxidant properties. It plays a role in cellular processes and metabolic function, particularly in energy production and mitochondrial support. ALA is frequently implemented to support glucose metabolism, nerve health, and liver detoxification. This supplement continues to be recognized for its role in biological processes related to oxidative balance and metabolic efficiency.
Category
Antioxidants
When To Take It
Alpha-lipoic acid is best taken on an empty stomach, either in the morning or before meals, to maximize absorption and effectiveness. It can also be taken before bedtime to support antioxidant and detoxification processes.
Synergy and Antagonism
Alpha-lipoic acid synergizes with vitamin C, vitamin E, and CoQ10, glutathione, and N-acetyl-cysteine (NAC) to enhance antioxidant function and energy production. However, it may have an antagonistic effect by interfering with vitamin B1 (thiamine) metabolism and reducing iron absorption when taken in high amounts.
Alpha-lipoic acid synergizes with vitamin C, vitamin E, and CoQ10, glutathione, and N-acetyl-cysteine (NAC) to enhance antioxidant function and energy production. However, it may have an antagonistic effect by interfering with vitamin B1 (thiamine) metabolism and reducing iron absorption when taken in high amounts.

Alpha-Lipoic Acid
May Help With The Following Conditions
At present, there is no established association between this supplement and any medical condition listed on the Health Status pages.
Warnings
Alpha-lipoic acid should be used with caution in individuals who are breastfeeding, have a thiamine deficiency, or consume alcohol regularly. It may interact with certain medications, such as antitumor antibiotics, thyroid hormones, alkylating agents, anticoagulants, and anti-diabetes medications. Consider supplementing with B vitamins, particularly thiamine, if taking alpha-lipoic acid regularly. Consulting a healthcare provider is recommended, especially if taking any of the aforementioned medications.