Description
"Gamma-Aminobutyric Acid" (GABA) is a naturally occurring amino acid that functions as the brain’s primary inhibitory neurotransmitter, essential for synaptic modulation and neural signaling. It participates in pathways that fine-tune excitatory activity, ensuring balanced cognitive responses. GABA also engages in biochemical interactions that influence circadian rhythms, stress resilience, and motor control. Through its role in neurotransmission, it contributes to metabolic regulation and nervous system stability. Integral to neurological function, GABA remains a key factor in emotional equilibrium and adaptation.
Functions in the Body
Category
Deficiency Symptoms
A deficiency in GABA may lead to increased anxiety, stress, worry, alcohol cravings, daytime sleepiness, difficulty relaxing, and sleep disturbances.
Synergists & Antagonists
GABA works synergistically with theanine and magnesium, which both promote relaxation and stress relief. Glutamate, the primary excitatory neurotransmitter, acts antagonistically to GABA, as they balance each other’s effects in the nervous system. Additionally, caffeine and other stimulants can antagonize GABA’s calming effects, increasing anxiety and stress.
Gamma-Aminobutyric Acid
Warnings
GABA supplementation may cause drowsiness, stomach upset, headaches, and muscle weakness. Use caution when combining GABA with alcohol, sedatives, or muscle relaxants, as these can amplify its effects.
Food Sources
GABA is not found in significant amounts in food, but fermented foods like kimchi, miso, sauerkraut, and tempeh can support its production in the body.
Time Frame
Best taken before bed to support sleep quality and promote relaxation.
Depleted By
Chronic stress, caffeine, and certain medications like antiparasitics may reduce GABA production or interfere with its effects.