Description
"Diamine Oxidase" (DAO) is an enzyme produced in the kidneys, thymus, and gastrointestinal lining, where it regulates histamine metabolism. This enzyme supports enzymatic pathways that break down dietary histamine, contributing to digestive homeostasis and histamine balance. It further affects biochemical processes involved in immune function and gut health. Additionally, DAO plays a role in mitigating histamine-related discomfort associated with food sensitivities. A vital factor in enzymatic regulation, it remains integral to gastrointestinal stability and metabolic function.
Functions in the Body
Category
Deficiency Symptoms
A deficiency in DAO may lead to symptoms such as migraines, headaches, gastrointestinal disorders, irritable bowel syndrome (IBS), skin disorders, atopic skin conditions, fibromyalgia, chronic fatigue, and possibly ADHD.
Synergists & Antagonists
DAO is an enzyme that aids in histamine breakdown, and vitamin B6 may enhance its function. There are no well-documented antagonistic interactions.
Diamine Oxidase
Warnings
DAO supplements are typically well-tolerated, with few side effects reported. However, those with significant histamine intolerance or digestive disorders should seek medical advice prior to supplementation to ensure proper use and safety.
Food Sources
DAO is not naturally found in foods but is available as a supplement to aid in the breakdown of histamine.
Time Frame
DAO supplements should be taken before meals to support the breakdown of histamine from food.
Depleted By
DAO levels can be depleted by factors such as alcohol, genetic mutations, intestinal bacterial overgrowth, and medications like heparin.