Description
Diamine Oxidase (DAO) is a crucial digestive enzyme produced primarily by the kidneys, thymus, and the gastrointestinal lining, where it plays a key role in the metabolism of histamine. Individuals with histamine intolerance often struggle to break down excess histamine, which can lead to uncomfortable symptoms like digestive issues, headaches, flushing, and allergic reactions. By supplementing with DAO, the body can more effectively metabolize histamine, promoting digestive comfort and alleviating symptoms associated with histamine overload. In addition to its role in histamine regulation, DAO also supports overall gut health by reducing inflammation and allergic reactions within the digestive tract. Regular use of DAO supplements can help manage histamine intolerance, promote a well-functioning digestive system, and enhance immune system balance.
Functions in the Body
Category
Deficiency Symptoms
A deficiency in DAO may lead to symptoms such as migraines, headaches, gastrointestinal disorders, irritable bowel syndrome (IBS), skin disorders, atopic skin conditions, fibromyalgia, chronic fatigue, and possibly ADHD.
Synergy & Antagonism
There are no well-documented synergistic or antagonistic interactions for diamine oxidase (DAO).
Diamine Oxidase
Warnings
DAO supplements are typically well-tolerated, with few side effects reported. However, those with significant histamine intolerance or digestive disorders should seek medical advice prior to supplementation to ensure proper use and safety.
Food Sources
DAO is not naturally found in foods but is available as a supplement to aid in the breakdown of histamine.
Time Frame
DAO supplements should be taken before meals to support the breakdown of histamine from food.
Depleted By
DAO levels can be depleted by factors such as alcohol, genetic mutations, intestinal bacterial overgrowth, and medications like heparin.