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Description
Citrulline is a non-essential amino acid naturally found in foods such as watermelon, squash, and cucumbers, and is also produced in the body. Once ingested, citrulline is converted by the kidneys into another amino acid, arginine, which plays a vital role in producing nitric oxide. Nitric oxide is essential for vasodilation, or the widening of blood vessels, which improves circulation and supports blood pressure regulation. By enhancing blood flow, citrulline is beneficial for maintaining cardiovascular health, improving muscle recovery, and boosting exercise performance. Additionally, citrulline helps reduce ammonia and lactic acid buildup, which can delay muscle fatigue and improve endurance during physical activity. Regular intake of citrulline-rich foods or supplements can promote vascular health, enhance physical performance, and support overall cardiovascular function.
Functions in the Body
Category
Deficiency Symptoms
Since citrulline is not an essential nutrient, there are no deficiency symptoms associated with its absence.
Synergy & Antagonism
Citrulline works synergistically with arginine and nitric oxide boosters to improve blood flow and exercise performance. There are no significant antagonistic interactions reported.
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Citrullin
Warnings
Caution is advised during pregnancy and breastfeeding, as the safety of citrulline supplementation has not been well established for these groups.
Food Sources
Natural food sources of citrulline include cucumbers, pumpkins, watermelon, cantaloupe, and squash.
Time Frame
Citrulline is best taken before a workout, as it may help improve exercise performance by supporting blood flow and reducing muscle fatigue.
Depleted By
There are no specific dietary or lifestyle factors that deplete citrulline.