Description
"Butyrate" is a short-chain fatty acid (SCFA) naturally generated in the colon through microbial fermentation of dietary fiber. This compound serves as an energy source for colonocytes, supporting gut barrier integrity and microbial equilibrium. It participates in metabolic signaling pathways, interacting with fermentation dynamics, nutrient absorption, and cellular processes. Its presence contributes to gastrointestinal stability, shaping microbial interactions and digestive efficiency. Naturally produced within a fiber-rich diet, butyrate remains essential for sustaining intestinal balance and metabolic regulation.
Functions in the Body
Category
Deficiency Symptoms
A deficiency in butyrate may result in poor immune function and digestive problems, as butyrate supports gut health and serves as a key energy source for colon cells.
Synergists & Antagonists
Butyrate is often combined with acetate, propionate, and prebiotic fiber for gut microbiome support. No known antagonistic effects exist.
Butyrate
Warnings
Be cautious when using butyrate supplements during pregnancy and breastfeeding. Consult a healthcare provider before use.
Food Sources
Butyrate is produced in the gut from the fermentation of dietary fiber and can be increased by consuming fiber-rich foods such as whole grains, barley, oats, apples, onions, berries, and citrus fruits.
Time Frame
Butyrate is best taken with meals to support digestion and gut health.
Depleted By
Butyrate levels can be depleted by a poor diet lacking in fiber and healthy prebiotic foods.