Description
r-Alpha-Lipoic Acid (rALA) is the naturally occurring and more bioavailable form of Alpha-Lipoic Acid, renowned for its powerful antioxidant properties. It plays a critical role in neutralizing free radicals and reducing oxidative stress, thus protecting cells from damage caused by environmental toxins and metabolic processes. rALA is essential for energy production, aiding in the conversion of carbohydrates into energy, which supports mitochondrial health and metabolic function. Its ability to regenerate other antioxidants, such as glutathione and vitamin C, boosts the body's overall defense system. Additionally, rALA helps regulate blood sugar levels, making it beneficial for individuals with diabetes or insulin resistance. It also plays a role in detoxifying the liver by chelating heavy metals and promoting liver health. rALA's ability to reduce inflammation and promote cardiovascular wellness underscores its importance for maintaining optimal health and metabolic balance.
Functions in the Body
Category
Deficiency Symptoms
Deficiency in alpha-lipoic acid is rare and typically occurs only in individuals with inherited mutations affecting the lipoic acid biosynthetic pathway.
Synergy & Antagonism
Alpha-lipoic acid (ALA) is commonly used with vitamin C, vitamin E, CoQ10, glutathione, and N-acetyl-cysteine (NAC) for antioxidant support and cellular energy production. However, excessive intake may deplete vitamin B1 (thiamine) levels and interfere with iron absorption.
Alpha-Lipoic Acid
Warnings
Caution is advised when using alpha-lipoic acid while breastfeeding, in cases of thiamine deficiency, or with alcohol consumption. It may lower blood sugar levels, so individuals on anti-diabetes medications or those with insulin sensitivity should monitor their blood sugar closely. Alpha-lipoic acid may also interact with medications such as antitumor antibiotics, thyroid hormones, alkylating agents, anticoagulants, and anti-diabetes drugs. Consult a healthcare provider before use.
Food Sources
Rich sources of alpha-lipoic acid include spinach, broccoli, potatoes, tomatoes, Brussels sprouts, carrots, and beets.
Time Frame
Alpha-lipoic acid is often taken before bedtime for its antioxidant and detoxification benefits during rest.
Depleted By
Alpha-lipoic acid is not naturally depleted by specific dietary or lifestyle factors, as it is synthesized in small amounts by the body and available through dietary sources.