Description
“Alpha-Lipoic Acid" (ALA) is an organic compound found in foods like spinach, broccoli, and red meat, as well as produced naturally by the body. It participates in energy metabolism by assisting mitochondrial activity and supporting glucose use. ALA also influences antioxidant pathways by regenerating glutathione and neutralizing free radicals, contributing to oxidative balance. Additionally, it interacts with liver enzymes to aid detoxification. As a key element of metabolic function, alpha-lipoic acid supports biochemical pathways involved in cellular health.
Functions in the Body
Category
Deficiency Symptoms
Deficiency in alpha-lipoic acid is rare and typically occurs only in individuals with inherited mutations affecting the lipoic acid biosynthetic pathway.
Synergists & Antagonists
Alpha-lipoic acid is commonly used with vitamin C, vitamin E, CoQ10, glutathione, and N-acetyl-cysteine for antioxidant support and cellular energy production. However, excessive intake may deplete vitamin B1 (thiamine) levels and interfere with iron absorption.
Alpha-Lipoic Acid
Warnings
Caution is advised when using alpha-lipoic acid while breastfeeding, in cases of thiamine deficiency, or with alcohol consumption. It may lower blood sugar levels, so individuals on anti-diabetes medications or those with insulin sensitivity should monitor their blood sugar closely. Alpha-lipoic acid may also interact with medications such as antitumor antibiotics, thyroid hormones, alkylating agents, anticoagulants, and anti-diabetes drugs. Consult a healthcare provider before use.
Food Sources
Rich sources of alpha-lipoic acid include spinach, broccoli, potatoes, tomatoes, Brussels sprouts, carrots, and beets.
Time Frame
Alpha-lipoic acid is often taken before bedtime for its antioxidant and detoxification benefits during rest.
Depleted By
Alpha-lipoic acid is not naturally depleted by specific dietary or lifestyle factors, as it is synthesized in small amounts by the body and available through dietary sources.