Description
Functions in the Body
5-MTHF (5-Methyltetrahydrofolate) is the bioactive form of vitamin B9 (folate) that the body can absorb and utilize more efficiently than folic acid. This compound is essential for DNA synthesis, repair, and healthy cell division, contributing to overall metabolism. 5-MTHF is critical during pregnancy, promoting fetal tissue development, and reducing the risk of neural tube defects. It also supports the production of red blood cells, helping prevent anemia and maintaining a robust immune system. Additionally, 5-MTHF is particularly beneficial for individuals with genetic variations like MTHFR mutations, which impair folic acid conversion, ensuring optimal folate status and overall health. Regular intake can support cardiovascular health, homocysteine regulation, and cognitive function, making it a vital nutrient for comprehensive health maintenance.
Deficiency Symptoms
Deficiency in 5-MTHF can result in megaloblastic anemia, characterized by abnormal red blood cell production.
Synergy & Antagonism
5-MTHF works synergistically with vitamin B2 (riboflavin) and vitamin B12 to improve folate metabolism. There are no well-documented antagonistic interactions.
5-MTHF
Warnings
A number of medications, including high doses of NSAIDs (e.g., Ibuprofen, Aspirin), anticonvulsants, cholesterol-lowering agents, methotrexate, trimethoprim, oral contraceptives, and blood pressure medications can interfere with folate metabolism. Consult your healthcare provider if you're on any of these medications.
Food Sources
Foods high in folate, a precursor to 5-MTHF, include turkey, chicken, pumpkin seeds, spinach, milk, bananas, broccoli, legumes, and asparagus.
Time Frame
5-MTHF can be taken at any time of day, with some experts recommending it in the early morning for best results.
Depleted By
5-MTHF levels can be depleted by alcohol, antacids, corticosteroids, anticonvulsants, sedatives, nicotine, laxatives, immunosuppressants, hormone replacement therapy, statins, caffeine, bronchodilators, antidepressants, NSAIDs, and various other medications including opioids, diuretics, and anti-cancer drugs.