Description
“5-MTHF" (5-Methyltetrahydrofolate) is the bioactive form of vitamin B9 (folate), naturally present in certain foods and readily utilized by the body. It plays a role in DNA synthesis, cellular repair, and methylation, supporting metabolic function. This compound is essential during pregnancy for fetal development and neural tube formation. 5-MTHF also contributes to red blood cell production and homocysteine metabolism. For individuals with MTHFR mutations, adequate dietary folate intake plays a key role in supporting metabolic balance and overall health.
Functions in the Body
Category
Deficiency Symptoms
Deficiency in 5-MTHF can result in megaloblastic anemia, characterized by abnormal red blood cell production.
Synergists & Antagonists
5-MTHF supports folate metabolism by working synergistically with vitamin B2 and vitamin B12. There are no well-documented antagonistic interactions.
5-Methyltetrahydrofolate
Warnings
A number of medications, including high doses of NSAIDs (e.g., Ibuprofen, Aspirin), anticonvulsants, cholesterol-lowering agents, methotrexate, trimethoprim, oral contraceptives, and blood pressure medications can interfere with folate metabolism. Consult your healthcare provider if you're on any of these medications.
Food Sources
Foods high in folate, a precursor to 5-MTHF, include turkey, chicken, pumpkin seeds, spinach, milk, bananas, broccoli, legumes, and asparagus.
Time Frame
5-MTHF can be taken at any time of day, with some experts recommending it in the early morning for best results.
Depleted By
5-MTHF levels can be depleted by alcohol, antacids, corticosteroids, anticonvulsants, sedatives, nicotine, laxatives, immunosuppressants, hormone replacement therapy, statins, caffeine, bronchodilators, antidepressants, NSAIDs, and various other medications including opioids, diuretics, and anti-cancer drugs.