Description
“5-Hydroxytryptophan" (5-HTP) is a naturally occurring compound derived from the amino acid L-tryptophan, essential for serotonin production. Serotonin plays a role in mood regulation, sleep cycles, and appetite control. While 5-HTP itself is not commonly found in foods, the body synthesizes it from L-tryptophan as part of serotonin metabolism. The availability of 5-HTP depends on dietary protein intake and enzymatic conversion. As a key serotonin precursor, it remains an important compound in neurotransmitter synthesis and overall neurological balance.
Functions in the Body
Category
Deficiency Symptoms
Low 5-HTP levels may result in symptoms like insomnia, depression, fibromyalgia, migraine, hot flashes, weight loss, and anxiety.
Synergists & Antagonists
5-HTP is often combined with vitamin B6 and magnesium to help support serotonin levels and mood balance. However, it may have an antagonistic effect when taken alongside antidepressant medications such as SSRIs, MAOIs, or carbidopa, which also influence serotonin metabolism.
5-Hydroxytryptophan
Warnings
Individuals with hypersensitivity to 5-HTP should avoid its use. Those who are pregnant, nursing, trying to conceive, or taking medications that influence serotonin levels should consult a healthcare provider before use.
Food Sources
Food sources of tryptophan, the precursor to 5-HTP, include turkey, chicken, pumpkin seeds, spinach, milk, bananas, potatoes, sunflower seeds, turnip greens, collard greens, and seaweed.
Time Frame
For regular use, take 5-HTP with meals. For sleep support, take 30 minutes before bedtime.
Depleted By
High levels of tyrosine may reduce 5-HTP availability in the body.