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Essential4Health

Get Healthy ~ Stay Healthy

Essential4Health

Get Healthy ~ Stay Healthy

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Wounds

injury-man-doctor-wounds
"Wounds" are physical injuries to the skin or underlying tissues that trigger a complex healing process involving clotting, inflammation, tissue growth, and remodeling. After bleeding stops, immune cells remove debris and pathogens, while fibroblasts produce collagen to repair damage. Nutrients like protein, zinc, and vitamin C are essential for proper healing. Chronic illness, poor circulation, or infection may delay recovery. Maintaining hygiene, applying wound care, and supporting the body with targeted nutrition help reduce scarring and restore tissue integrity.

Description

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"Wounds" are physical injuries to the skin or underlying tissues that trigger a complex healing process involving clotting, inflammation, tissue growth, and remodeling. After bleeding stops, immune cells remove debris and pathogens, while fibroblasts produce collagen to repair damage. Nutrients like protein, zinc, and vitamin C are essential for proper healing. Chronic illness, poor circulation, or infection may delay recovery. Maintaining hygiene, applying wound care, and supporting the body with targeted nutrition help reduce scarring and restore tissue integrity.

Symptoms & Signs

Body System

Causes

Injuries, Surgery, Accidents, Diabetes, Edema, Chronic Bacterial Infections, Immobility

Things To Do

To better support our bodies in wound healing, it is best to include:


  • a whole-foods-based diet consisting of fresh vegetables, fruits, meats, fish, legumes, whole grains, and healthy fats.

  • a large variety of fruits and vegetables that will provide antioxidant and anti-inflammatory properties as well as replenish micronutrients.

  • good fats. Consume nuts, seeds, avocados, fatty fish, and coconut and olive oils. They strengthen the immune system, facilitate the absorption of numerous fat-soluble vitamins, and aid in the prevention of infections.

  • whole foods high in E, C, and A vitamins. These vitamins support the healing of wounds.

  • Whole foods that are high in B vitamins. B vitamins promote wound healing and energy production.

  • whole foods high in zinc. Zinc aids in skin integrity restoration.

  • omega-3 fatty acids, which boost the immune system and prevent infections.

  • probiotic-rich foods that strengthen the immune system and gut health.

  • Eat whole grains, legumes, fruits, and vegetables to get your carbs.

  • sufficient hydration.


Furthermore, incorporate the following:


  • care for external wounds: wash your hands before handling the wound. Clean and disinfect the wound. Apply a clean bandage. Change the bandage every day, keep your wound clean and dry, and watch out for signs of infection. Consult a doctor if your wound is extensive and needs stitches or other forms of medical care.

  • internal wound care: get a lot of rest and let your body heal them naturally. Adjust your diet and stay hydrated. Monitor your body's temperature and pain sensations. Increased pain in the area may indicate a problem. 

  • get enough quality sleep. Sleep boosts immune function, detoxifies, and speeds up wound healing.

  • reduce the number of daily activities according to your condition. 

  • reduce stress.

  • seek medical help if your wound isn't healing properly. You may notice a yellow discharge or puss. 

Things To Avoid

The list of foods and ingredients that do not support wound healing includes the following:


  • processed, fast food, and junk food. They are inflammatory and do not support a healthy metabolism or the healing of wounds.

  • sugar, sweets made artificially, candies, desserts, soft drinks, etc. Sugar causes inflammation, and elevated blood sugar inhibits the healing of wounds.

  • Refined carbohydrates. They lack fiber, harm the gastrointestinal system, and weaken the immune system.

  • caffeine, and alcohol. Both caffeine and alcohol can dehydrate the body, and alcohol causes inflammation in the body.

  • sodium-rich processed foods. A high-sodium diet increases inflammation and contributes to the formation of hypertrophic scars.

  • trans fats and hydrogenated vegetable oils. They are highly inflammatory.

  • Insufficient water intake.


Furthermore, avoid the following:


  • Smoking, which impedes wound healing and recovery. It creates systemic inflammation.

  • Leaving the same bandage for too long, getting it wet, or getting it dirty. 

  • Streunous activities, such as lifting and exercising.

  • poor sleep. Sleep disturbances and short sleep durations may impede recovery.

  • ignoring bleeding, not removing debris, and not cleaning the wound properly. 

  • ignoring the impact of your health condition [diabetes, insulin resistance, edema, etc.] on the process of wound healing.

Supplements

Direct Support

(Most Helpful → Least Helpful)

These supplements directly affect wound healing by supporting tissue regeneration, reducing inflammation, or enhancing collagen formation and immune defense.

  1. Zinc: Zinc plays an essential role in wound healing by promoting tissue re-epithelialization, controlling inflammation, and aiding in scar formation. Its regenerative properties help speed up the healing process and improve tissue recovery.

  2. Vitamin C: Vitamin C supports collagen synthesis, which strengthens tissue repair, and boosts the immune response to help fight infections. Its antioxidant properties speed up wound healing and improve skin regeneration.

  3. Collagen/Elastin/Hyaluronic Acid: Collagen enhances tissue strength and elasticity, crucial for wound repair, while hyaluronic acid supports skin regeneration and reduces inflammation. Together, they accelerate healing and promote more resilient tissue formation.

  4. Vitamin A: Vitamin A accelerates wound healing by promoting collagen production and epithelialization. It aids in forming new tissues and supports skin regeneration, helping wounds heal faster and more effectively.

  5. N-Acetyl-L-Cysteine [NAC]: NAC stimulates the formation of new blood vessels (angiogenesis) and scavenges harmful free radicals, creating a supportive environment for wound recovery. It helps reduce oxidative stress, speeding up the overall healing process.

  6. Serrapeptase: Serrapeptase reduces inflammation and swelling while breaking down scar tissue. By actively promoting tissue metabolism, it supports a more comprehensive healing process, leading to faster and cleaner wound recovery.

  7. Nattokinase: Nattokinase, a fibrinolytic enzyme, aids wound healing by breaking down scar tissue and improving circulation. Its ability to enhance blood flow promotes smoother recovery and reduces the risk of excessive scar formation.

  8. Vitamin E: Vitamin E helps heal wounds by protecting cells from oxidative damage and promoting skin regeneration. Its antioxidant properties support faster tissue repair and improve overall skin recovery.

  9. Papain: Serrapeptase reduces inflammation and swelling while breaking down scar tissue. By actively promoting tissue metabolism, it supports a more comprehensive healing process.

Indirect Support

(Most Helpful → Least Helpful)

These supplements do not target wounds directly but may support circulation, improve nutrient absorption, or strengthen the immune system to aid healing.

  1. Digestive Enzymes: Digestive enzymes enhance nutrient absorption, ensuring the body gets the essential vitamins and minerals needed for wound healing. By promoting better nutrient uptake, they facilitate faster tissue repair and recovery.

Natural Compounds

These natural compounds may help manage wounds by supporting skin repair, improving hydration, or aiding in the regeneration of damaged tissue.

  1. Manuka Honey: Manuka honey’s antibacterial properties help prevent infections while maintaining a moist healing environment. This supports faster wound closure and promotes smoother healing, making it ideal for effective wound care.

  2. Propolis: Propolis promotes tissue repair by reducing infection risks through its antimicrobial and anti-inflammatory properties. It accelerates wound healing and ensures cleaner recovery by preventing bacterial growth.

  3. Coconut Oil: Coconut oil promotes collagen production, supporting faster wound healing and improving skin barrier function. Its anti-inflammatory and antimicrobial properties prevent infections and aid in smoother recovery.

  4. Olive Oil: Olive oil reduces oxidative stress and inflammation, promoting faster tissue repair and wound closure. Its rich antioxidant content supports skin regeneration and helps reduce scar formation for smoother healing.

  5. Colloidal Silver: Colloidal silver acts as an antimicrobial agent, preventing infections and creating a protective barrier on wounds. It speeds up healing by reducing bacterial contamination and promoting a cleaner recovery process.

  6. Beeswax: Beeswax forms a protective barrier that locks in moisture and supports tissue regeneration. Its anti-inflammatory properties help reduce swelling and promote faster wound recovery by preventing infection.

Plant Extracts

Direct Support

(Most Helpful → Least Helpful)

These plant extracts directly support wound healing by providing antimicrobial protection, reducing inflammation, or promoting tissue repair and regeneration.

  1. Gotu Kola Extract: Gotu kola enhances collagen production and strengthens newly formed skin, supporting faster wound healing and reducing the formation of scars. It also improves skin elasticity and promotes complete tissue recovery.

  2. Aloe Vera Gel: Aloe vera gel accelerates wound healing by increasing collagen production and promoting cell migration. Its soothing and anti-inflammatory effects support skin regeneration and reduce the formation of scars.

  3. Calendula Oil: Calendula promotes tissue regeneration and epithelialization, speeding up wound healing and making it highly effective for burns, cuts, and various skin injuries. It also supports faster recovery by reducing inflammation.

  4. Bromelain: Bromelain helps break down necrotic tissue, promoting wound cleaning and speeding up the healing process. Its anti-inflammatory effects support tissue regeneration, reduce swelling, and enhance overall recovery.

  5. Boswellia Serrata: Boswellia serrata improves wound contraction and stabilizes collagen by boosting hydroxyproline levels, which accelerates healing, particularly in burns. Its anti-inflammatory properties help reduce swelling and promote faster tissue recovery.

  6. Grape Seed Extract: Grape seed extract accelerates wound healing by enhancing collagen formation and stimulating fibroblast activity, which supports faster wound closure and tissue repair.

  7. Lavender Essential Oil: Lavender essential oil reduces inflammation and prevents infections, promoting faster wound healing. Its strong antimicrobial properties make it beneficial for treating cuts, burns, and scars, supporting smoother skin recovery.

  8. Tea Tree Essential Oil: Tea tree essential oil provides strong antimicrobial action that prevents infection and supports tissue repair. It promotes faster wound healing and lowers the risk of complications.

Indirect Support

(Most Helpful → Least Helpful)

These extracts do not act directly on wounds but may support detoxification, enhance immune response, or reduce oxidative stress involved in healing.

  1. Grapefruit Seed Extract - Grapefruit seed promotes blood vessel regeneration and supports moderate free radical production at wound sites, which aids in healing. It reduces inflammation and enhances the overall wound recovery process.

Alternative Treatments

These alternative therapies support wound recovery, promote tissue regeneration, and reduce inflammation in individuals healing from injuries.

  1. Hyperbaric Chamber Therapy: Hyperbaric chamber therapy enhances wound healing by increasing oxygen delivery to tissues, promoting collagen synthesis, and reducing inflammation. It’s particularly effective for chronic wounds or those with poor circulation.

  2. Ozone IV: Ozone IV therapy boosts oxygen delivery to tissues, reducing bacterial infections and stimulating tissue repair. It enhances natural healing processes by improving cellular oxygenation, promoting faster recovery.

  3. Ultraviolet Light Therapy: Ultraviolet light disinfects wounds by killing bacteria and promoting faster epithelialization, making it effective in managing chronic wounds prone to infection and supporting quicker healing.

  4. Hydrotherapy: Hydrotherapy enhances circulation, reduces swelling, and promotes tissue regeneration, making it beneficial for treating burns and chronic wounds. Its soothing effects also help relieve pain and accelerate the healing process.

  5. Transcutaneous Electrical Nerve Stimulation [TENS]: TENS stimulates blood circulation, reduces pain, and promotes tissue repair, enhancing the healing process in chronic wounds while alleviating discomfort.

  6. Acupuncture: Acupuncture stimulates blood circulation and improves tissue regeneration by targeting points like ST36 (Zusanli) below the knee and LI4 (Hegu) on the hand. This increases blood flow, reduces inflammation, and promotes faster wound healing.

  7. Massage Therapy: Massage therapy improves blood circulation and reduces the formation of scar tissue, supporting wound healing after closure. It enhances tissue flexibility and eases discomfort, helping to prevent tightness and stiffness in the healing area.

Books That You May Want To Read

Podcast Episodes To Listen To

Educational Videos To Learn From

Functional Lab Tests That You Might Consider

How Key Nutrients Support the Body

Amino Acids: Amino acids serve as the building blocks of proteins, crucial for muscle growth and repair. Additionally, they play key roles in maintaining proper pH levels, storing nitrogen, synthesizing hormones, and facilitating enzymatic reactions.


Enzymes and Coenzymes: Enzymes catalyze biochemical reactions, while coenzymes assist in these processes by binding temporarily to enzymes. Together, they regulate digestion, energy production, immune responses, and various metabolic pathways.


Herbal Extracts: Herbal extracts contain bioactive compounds with various medicinal properties, including antioxidant, anti-inflammatory, and antimicrobial effects. They have been used traditionally to support digestion, immunity, and overall health.


Minerals: Minerals are essential for various physiological functions, including bone health, nerve transmission, and enzyme activity. They support overall health by ensuring proper cellular function and metabolic processes.


Vitamins: Vitamins are essential micronutrients that play diverse roles in supporting cellular processes, immune function, and overall health. They must be obtained through diet or supplementation to ensure proper bodily function.

Essential Nutrients Explained

References

[1] Jadhav SB, Shah N, Rathi A, Rathi V, Rathi A. Serratiopeptidase: Insights into the therapeutic applications. Biotechnol Rep (Amst). 2020;28:e00544.
[2] Gupte V, Luthra U. Analytical techniques for serratiopeptidase: A review. J Pharm Anal. 2017;7(4):203-207.
[3] Chen H, McGowan EM, Ren N, et al. Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases. Biomark Insights. 2018;13.
[4] Midgley AC, Oltean S, Hascall V, et al. Nuclear Hyaluronidase 2 Drives Alternative Splicing Of Cd44 Pre-Mrna To Determine Profibrotic Or Antifibrotic Cell Phenotype. Science Signaling. 2017, 21.
[5] Takabayashi T, Imoto Y, Sakashita M, et al. Nattokinase, profibrinolytic enzyme, effectively shrinks the nasal polyp tissue and decreases viscosity of mucus. Allergol Int. 2017;66(4):594-602.
[6] Sahbaz A, Aynioglu O, Isik H, et al. Bromelain: A natural proteolytic for intra-abdominal adhesion prevention. International Journal of Surgery. 2015, Vol 14, pp 7-11.
[7] Rathnavelu V, Alitheen NB, Sohila S, Kanagesan S, Ramesh R. Potential role of bromelain in clinical and therapeutic applications. Biomed Rep. 2016;5(3):283-288.
[8] Aichele K, Bubel M, Deubel G, Pohlemann T, Oberringer M. Bromelain down-regulates myofibroblast differentiation in an in vitro wound healing assay. Naunyn Schmiedebergs Arch Pharmacol. 2013;386(10):853-863.
[9] Chen YY, Lu YH, Ma CH, et al. A novel elastic liposome for skin delivery of papain and its application on hypertrophic scar. Biomedicine & Pharmacotherapy. 2017, 87. 82-91.
[10] Leite AP, de Oliveira BG, Soares MF, Barrocas DL. Uso e efetividade da papaína no processo de cicatrização de feridas: uma revisão sistemática [Use and effectiveness of papain in the wound healing process: a systematic review]. Rev Gaucha Enferm. 2012;33(3):198-207.
[11] Fauzan HJ. Effect of Papain Enzymes on the Density and Amount of Collagen in Scar Tissue in rats. IOSR-JDMS. 2018, Vol 17, Issue 12 Version 7, pp 47-53.
[12] Porsani MYH, Carvalho LAR, Pereira CS, Paludetti M, Zangeronimo MG, Pereira LJ. The use of papain gel cream and sunflower oil in promoting healing in a wound in dogs: three case reports. Arquivo Brasileiro de Medicina Veterinária e Zootecnia. 2016, 68(5), 1201-1206.
[13] Rachmi Fanani H, Fakhrurrazi, Dinni. Effect of Carica papaya Extract toward Incised Wound Healing Process in Mice (Mus musculus) Clinically and Histologically. Evidence-Based Complementary and Alternative Medicine. 2019.
[14] Ohio State University. Grape Seed Extract Help Speed Up Wound Recovery, Study Suggests. 2002, Dec.
[15] Han M, Sağlıyan A, Benzer F, et al. Beneficial effects of oral administrations of grape seed extract on healing of surgically induced skin wounds in rabbits. Revue de médecine vétérinaire. 2012, 163. 11-17.
[16] Moalla Rekik D, Ben Khedir S, Ksouda Moalla K, Kammoun NG, Rebai T, Sahnoun Z. Evaluation of Wound Healing Properties of Grape Seed, Sesame, and Fenugreek Oils. Evid Based Complement Alternat Med. 2016;2016:7965689.
[17] Rajakumari R, Volova T, Oluwafemi OS, et al. Nano formulated proanthocyanidins as an effective wound healing component. Materials Science and Engineering. 2020, C, 106.
[18] Han X, Rodriguez D, Parker TL. Biological activities of frankincense essential oil in human dermal fibroblasts. Biochim Open. 2017;4:31-35.
[19] Shedoeva A, Leavesley D, Upton Z, Fan C. Wound Healing and the Use of Medicinal Plants. Evidence-Based Complementary and Alternative Medicine. 2019.
[20] Hou Q, He WJ, Hao HJ, Han QW, Chen L, et al. The Four-Herb Chinese Medicine ANBP Enhances Wound Healing and Inhibits Scar Formation via Bidirectional Regulation of Transformation Growth Factor Pathway. Plos One. 2014, 9(12): e112274.
[21] Sun L, Wu D, Ning X, et al. α-Amylase-assisted extraction of polysaccharides from Panax ginseng. Int J Biol Macromol. 2015;75:152-157.
[22] Tiwari S, Srivastava R, Singh C, et al. Amylases: an overview with special reference to alpha amylase. Journal of Global Biosciences. 2015, 4. 1886-1901.
[23] James JA, Lee BH. Glucoamylases: Microbial Sources, Industrial Applications And Molecular Biology — A Review. Journal Of Food Biochemistry. 1997, 21: 1-52.
[24] Zhitkovich A. N-Acetylcysteine: Antioxidant, Aldehyde Scavenger, and More. Chemical Research in Toxicology 2019 32 (7), 1318-1319.
[25] Chu DI, Lim R, Heydrick S, et al. N-acetyl-l-cysteine decreases intra-abdominal adhesion formation through the upregulation of peritoneal fibrinolytic activity and antioxidant defenses. Surgery. 2011;149(6):801-812.
[26] Ozkaya H, Omma T, Murat Y, et al. Topical and Systemic Effects of N-acetyl Cysteine on Wound Healing in a Diabetic Rat Model. Wounds. 2019;31(4):91–96.
[27] Janeczek M, Moy L, Riopelle A, et al. The Potential Uses of N-acetylcysteine in Dermatology: A Review. The Journal of Clinical and Aesthetic Dermatology. 2019, 12(5):20-26.
[28] Yosef B, Zhou Y, Mouschouris K, et al. N-Acetyl-L-Cysteine Reduces Fibrosis and Improves Muscle Function After Acute Compartment Syndrome Injury. Military Medicine. 2020, Vol 185, Issue Supplement_1, January-February, pp 25–34.
[29] Polcz ME, Barbul A. The role of vitamin A in wound healing. Nutrition in Clinical Practice. 2019 Oct;34(5):695-700.
[30] Hunt TK. Vitamin A and wound healing. Journal of the American Academy of Dermatology. 1986 Oct 1;15(4):817-21.
[31] Neuman MG, Nanau RM, Oruña-Sanchez L, Coto G. Hyaluronic acid and wound healing. Journal of pharmacy & pharmaceutical sciences. 2015 Jan 29;18(1):53-60.
[32] Voigt J, Driver VR. Hyaluronic acid derivatives and their healing effect on burns, epithelial surgical wounds, and chronic wounds: A systematic review and meta‐analysis of randomized controlled trials. Wound repair and regeneration. 2012 May;20(3):317-31.
[33] Gardeazabal L, Izeta A. Elastin and collagen fibres in cutaneous wound healing. Experimental Dermatology. 2024 Mar;33(3):e15052.
[34] Lamme EN, De Vries HJ, van Veen HE, Gabbiani G, Westerhof W, Middelkoop E. Extracellular matrix characterization during healing of full-thickness wounds treated with a collagen/elastin dermal substitute shows improved skin regeneration in pigs. Journal of Histochemistry & Cytochemistry. 1996 Nov;44(11):1311-22.
[35] Mathew-Steiner SS, Roy S, Sen CK. Collagen in wound healing. Bioengineering. 2021 May 11;8(5):63.
[36] Lansdown AB, Mirastschijski U, Stubbs N, Scanlon E, Ågren MS. Zinc in wound healing: theoretical, experimental, and clinical aspects. Wound repair and regeneration. 2007 Jan;15(1):2-16.
[37] Lin PH, Sermersheim M, Li H, Lee PH, Steinberg SM, Ma J. Zinc in wound healing modulation. Nutrients. 2017 Dec 24;10(1):16.
[38] Musalmah M, Fairuz AH, Gapor MT, Wan Ngah WZ. Effect of vitamin E on plasma malondialdehyde, antioxidant enzyme levels and the rates of wound closures during wound healing in normal and diabetic rats. Asia Pacific Journal of Clinical Nutrition. 2002 Oct;11:S448-51.
[39] Simon GA, Schmid P, Reifenrath WG, van Ravenswaay T, Stuck BE. Wound healing after laser injury to skin—the effect of occlusion and vitamin E. Journal of pharmaceutical sciences. 1994 Aug 1;83(8):1101-6.
[40] Moores J. Vitamin C: a wound healing perspective. British journal of community nursing. 2013 Dec 1;18(Sup12):S6-11.
[41] Ringsdorf Jr WM, Cheraskin E. Vitamin C and human wound healing. Oral Surgery, Oral Medicine, Oral Pathology. 1982 Mar 1;53(3):231-6.
[42] Xu B, Duan Y, Yu D, Jia P. Biological activity and mechanism of action of Gotu kola oil in skin wound repair. Tropical Journal of Pharmaceutical Research. 2024 May 10;23(4):691-4.
[43] Hardaningtyas K. Extract Potential Gotu Kola Leaf (Centella Asiatica L.) In Accelerating Burn Wound Healing. Jurnal EduHealth. 2024 Jul 11;15(03):248-61.
[44] Liang J, Cui L, Li J, Guan S, Zhang K, Li J. Aloe vera: a medicinal plant used in skin wound healing. Tissue Engineering Part B: Reviews. 2021 Oct 1;27(5):455-74.
[45] Khan AW, Kotta S, Ansari SH, Sharma RK, Kumar A, Ali J. Formulation development, optimization and evaluation of aloe vera gel for wound healing. Pharmacognosy magazine. 2013 Oct;9(Suppl 1):S6.
[46] Givol O, Kornhaber R, Visentin D, Cleary M, Haik J, Harats M. A systematic review of Calendula officinalis extract for wound healing. Wound repair and regeneration. 2019 Sep;27(5):548-61.
[47] Preethi KC, Kuttan R. Wound healing activity of flower extract of Calendula offlcinalis. Journal of basic and clinical physiology and pharmacology. 2009 Mar;20(1):73-80.
[48] Nicolaus C, Junghanns S, Hartmann A, Murillo R, Ganzera M, Merfort I. In vitro studies to evaluate the wound healing properties of Calendula officinalis extracts. Journal of ethnopharmacology. 2017 Jan 20;196:94-103.
[49] Samuelson R, Lobl M, Higgins S, Clarey D, Wysong A. The effects of lavender essential oil on wound healing: A review of the current evidence. The Journal of Alternative and Complementary Medicine. 2020 Aug 1;26(8):680-90.
[50] Vakilian K, Atarha M, Bekhradi R, Chaman R. Healing advantages of lavender essential oil during episiotomy recovery: a clinical trial. Complementary therapies in clinical practice. 2011 Feb 1;17(1):50-3.
[51] Chin KB, Cordell B. The effect of tea tree oil (Melaleuca alternifolia) on wound healing using a dressing model. The Journal of Alternative and Complementary Medicine. 2013 Dec 1;19(12):942-5.
[52] Halcón L, Milkus K. Staphylococcus aureus and wounds: a review of tea tree oil as a promising antimicrobial. American journal of infection control. 2004 Nov 1;32(7):402-8.
[53] Alvarez-Suarez JM, Gasparrini M, Forbes-Hernández TY, Mazzoni L, Giampieri F. The composition and biological activity of honey: a focus on Manuka honey. Foods. 2014 Jul 21;3(3):420-32.
[54] Gethin G, Cowman S. Case series of use of Manuka honey in leg ulceration. International Wound Journal. 2005 Mar;2(1):10-5.
[55] Oryan A, Alemzadeh E, Moshiri A. Potential role of propolis in wound healing: Biological properties and therapeutic activities. Biomedicine & pharmacotherapy. 2018 Feb 1;98:469-83.
[56] Rojczyk E, Klama-Baryła A, Łabuś W, Wilemska-Kucharzewska K, Kucharzewski M. Historical and modern research on propolis and its application in wound healing and other fields of medicine and contributions by Polish studies. Journal of Ethnopharmacology. 2020 Nov 15;262:113159.
[57] Nevin KG, Rajamohan T. Effect of topical application of virgin coconut oil on skin components and antioxidant status during dermal wound healing in young rats. Skin pharmacology and physiology. 2010 Jun 3;23(6):290-7.
[58] Soliman AM, Lin TS, Ghafar NA, Das S. Virgin coconut oil and diabetic wound healing: histopathological and biochemical analysis. Eur. j. anat. 2018 Mar 1;22(2):135-44.
[59] Donato-Trancoso A, Monte-Alto-Costa A, Romana-Souza B. Olive oil-induced reduction of oxidative damage and inflammation promotes wound healing of pressure ulcers in mice. Journal of dermatological science. 2016 Jul 1;83(1):60-9.
[60] Melguizo-Rodríguez L, de Luna-Bertos E, Ramos-Torrecillas J, Illescas-Montesa R, Costela-Ruiz VJ, García-Martínez O. Potential effects of phenolic compounds that can be found in olive oil on wound healing. Foods. 2021 Jul 15;10(7):1642.
[61] Alto Costa AM, Donnato‐Trancoso A, Romana‐Souza B. Olive oil administration improves cutaneous wound healing of pressure ulcers in mice. The FASEB Journal. 2016 Apr;30:1036-5.
[62] Ovais M, Ali A, Ullah S, Khalil AT, Atiq A, Atiq M, Dogan N, Shinwari ZK, Abbas M. Fabrication of colloidal silver-peptide nanocomposites for bacterial wound healing. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2022 Oct 20;651:129708.
[63] Nair HK. Nano-colloidal silver and chitosan bioactive wound dressings in managing diabetic foot ulcers: case series. Journal of wound care. 2018 Sep 1;27(Sup9a):S32-6.
[64] Kim HC. Development of a Novel Wound-Healing Patch using Honeybee’s Beeswax and Propolis. International Journal of High School Research. 2024 Feb 1;6(2).
[65] Bayir Y, Un H, Ugan RA, Akpinar E, Cadirci E, Calik I, Halici Z. The effects of Beeswax, Olive oil and Butter impregnated bandage on burn wound healing. Burns. 2019 Sep 1;45(6):1410-7.
[66] Chen TY, Wen TK, Dai NT, Hsu SH. Cryogel/hydrogel biomaterials and acupuncture combined to promote diabetic skin wound healing through immunomodulation. Biomaterials. 2021 Feb 1;269:120608.
[67] Lee JA, Jeong HJ, Park HJ, Jeon S, Hong SU. Acupuncture accelerates wound healing in burn-injured mice. Burns. 2011 Feb 1;37(1):117-25.
[68] Bhutani S, Vishwanath G. Hyperbaric oxygen and wound healing. Indian Journal of Plastic Surgery. 2012 May;45(02):316-24.
[69] Broussard CL. Hyperbaric oxygenation and wound healing. Journal of vascular nursing. 2004 Jun 1;22(2):42-8.
[70] Burke DT, Ho CH, Saucier MA, Stewart G. Effects of hydrotherapy on pressure ulcer healing1. American journal of physical medicine & rehabilitation. 1998 Sep 1;77(5):394-8.
[71] Tiglis M, Peride I, Neagu TP, Raducu L, Lascar I. Hydrotherapy in burn care: Pros, cons and suggestions. Romanian medical JouRnal. 2022 Jan 1;69(1):15.
[72] Isworo A. Combination of Wound Treatment and Massage for Healing Diabetic Foot Ulcers. International Journal of Nursing Education. 2021 Jan 1;13(1).
[73] Elazazy HM. Effect of skin rehabilitation massage therapy on burned patient outcomes. Journal of Health, Medicine and Nursing. 2018;47:99-111.
[74] Fitzpatrick E, Holland OJ, Vanderlelie JJ. Ozone therapy for the treatment of chronic wounds: A systematic review. International wound journal. 2018 Aug;15(4):633-44.
[75] Pchepiorka R, Moreira MS, da Silva Lascane NA, Catalani LH, Allegrini Jr S, de Lima NB. Effect of ozone therapy on wound healing in the buccal mucosa of rats. Archives of Oral Biology. 2020 Nov 1;119:104889.
[76] Davis KE, Bills J, Noble D, Crisologo PA, Lavery LA. Ultraviolet-A Light and Negative-Pressure Wound Therapy to Accelerate Wound Healing and Reduce Bacterial Proliferation. Journal of the American Podiatric Medical Association. 2023 Jan 1;113(1).
[77] Aleem NA, Aslam M, Zahid MF, Rahman AJ, Rehman FU. Treatment of burn wound infection using ultraviolet light: a case report. Journal of the American College of Clinical Wound Specialists. 2013 Apr 1;5(1):19-22.
[78] Thakral G, LaFontaine J, Najafi B, Talal TK, Kim P, Lavery LA. Electrical stimulation to accelerate wound healing. Diabetic foot & ankle. 2013 Jan 1;4(1):22081.
[79] Gürgen SG, Sayın O, Çetin F, Tuç Yücel A. Transcutaneous electrical nerve stimulation (TENS) accelerates cutaneous wound healing and inhibits pro-inflammatory cytokines. Inflammation. 2014 Jun;37:775-84.
[80] Hemmati AA, Houshmand G, Moosavi ZB, Bahadoram M, Maram NS. The topical effect of grape seed extract 2% cream on surgery wound healing. Global journal of health science. 2015 May;7(3):52.
[81] Carullo G, Sciubba F, Governa P, Mazzotta S, Frattaruolo L, Grillo G, Cappello AR, Cravotto G, Di Cocco ME, Aiello F. Mantonico and pecorello grape seed extracts: Chemical characterization and evaluation of in vitro wound-healing and anti-inflammatory activities. Pharmaceuticals. 2020 May 14;13(5):97.
[82] Izadpanah A, Soorgi S, Geraminejad N. Effect of grape seed extract ointment on cesarean section wound healing: A double-blind, randomized, controlled clinical trial. Complementary Therapies in Clinical Practice. 2019 May 1;35:323-8.

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