PROSTATE HEALTH
Description
Body System
[1] Ghorbanibirgani A, Khalili A, Zamani L. The efficacy of stinging nettle (urtica dioica) in patients with benign prostatic hyperplasia: a randomized double-blind study in 100 patients. Iran Red Crescent Med J. 2013;15(1):9-10.
[2] Wong KV. Stinging Nettles for Benign Prostatic Hyperplasia and Other Health Benefits. EC Nutrition. 2016, 5.5, 1228- 1231.
[3] Konrad L, Müller HH, Lenz C, Laubinger H, Aumüller G, Lichius JJ. Antiproliferative effect on human prostate cancer cells by a stinging nettle root (Urtica dioica) extract. Planta Med. 2000;66(1):44-47.
[4] Men C, Wang M, Aiyireti M, Cui Y. The Efficacy And Safety Of Urtica Dioica In Treating Benign Prostatic Hyperplasia: A Systematic Review And Meta-Analysis. Men et al., Afr J Tradit Complement Altern Med. 2016, 13(2):143-150.
[5] Johnson JJ, Bailey HH, Mukhtar H. Green tea polyphenols for prostate cancer chemoprevention: a translational perspective. Phytomedicine. 2010;17(1):3-13.
[6] Miyata Y, Shida Y, Hakariya T, Sakai H. Anti-Cancer Effects of Green Tea Polyphenols Against Prostate Cancer. Molecules. 2019;24(1):193.
[7] Khan N, Adhami VM, Mukhtar H. Review: Green Tea Polyphenols in Chemoprevention of Prostate Cancer: Preclinical and Clinical Studies. Nutrition and Cancer. 2009, 61:6, pages 836-841.
[8] H. Lee Moffitt Cancer Center & Research Institute. Component in green tea may help reduce prostate cancer in men at high risk. ScienceDaily. 2015, May.
[9] Teiten MH, Gaascht F, Eifes S, Dicato M, Diederich M. Chemopreventive potential of curcumin in prostate cancer. Genes Nutr. 2010;5(1):61-74.
[10] Piantino CB, Salvadori FA, Ayres PP, et al. An evaluation of the anti-neoplastic activity of curcumin in prostate cancer cell lines. International braz j urol. 2009, 35(3), 354-361.
[11] Killian PH, Kronski E, Michalik KM, et al. Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and -2 . Carcinogenesis. 2012, Vol 33, Issue 12, pp 2507–2519.
[12] Dorai T, Gehani N, Katz A. Therapeutic potential of curcumin in human prostate cancer Ð I. curcumin induces apoptosis in both androgen-dependent and androgen-independent prostate cancer cells. Department of Urology, Columbia University, College of Physicians and Surgeons, New York. Prostate Cancer and Prostatic Diseases. 2000, 3, 84±93.
[13] Rao KVK, Boukli NM, Samikkannu T, et al. Proteomics Profiling and Cytotoxic Effect of Curcuma longa on Prostate Cancer. The Open Proteomics Journal. 2011, 4, 1-11.
[14] Dai Q, Motley SS, Smith JA Jr, Concepcion R, Barocas D, et al. Blood Magnesium, and the Interaction with Calcium, on the Risk of High-Grade Prostate Cancer. PLOS ONE. 2011, 6(4): e18237.
[15] Huang H, Chen X, Li D, He Y, Li Y, et al. Combination of α-Tomatine and Curcumin Inhibits Growth and Induces Apoptosis in Human Prostate Cancer Cells. PLOS ONE. 2015, 10(12): e0144293.
[16] Santos JM, Hussain F. Magnesium Chloride increases apoptosis and decreases prostate cancer cells migration. Functional Foods in Health and Disease. 2018; 8(1):62-78.
[17] Di Silverio F, Monti S, Sciarra A, et al. Effects of long-term treatment with Serenoa repens (Permixon) on the concentrations and regional distribution of androgens and epidermal growth factor in benign prostatic hyperplasia. Prostate. 1998;37(2):77-83.
[18] Marks LS, Hess DL, Dorey FJ, Luz Macairan M, Cruz Santos PB, Tyler VE. Tissue effects of saw palmetto and finasteride: use of biopsy cores for in situ quantification of prostatic androgens. Urology. 2001;57(5):999-1005.
[19] Wadsworth TL, Carroll JM, Mallinson RA, Roberts CT Jr, Roselli CE. Saw palmetto extract suppresses insulin-like growth factor-I signaling and induces stress-activated protein kinase/c-Jun N-terminal kinase phosphorylation in human prostate epithelial cells. Endocrinology. 2004;145(7):3205-3214.
[20] Opoku-Acheampong AB, Penugonda K, Lindshield BL. Effect of Saw Palmetto Supplements on Androgen-Sensitive LNCaP Human Prostate Cancer Cell Number and Syrian Hamster Flank Organ Growth. Evidence-Based Complementary and Alternative Medicine. 2016.
[21] Jiang L, Zhao X, Xu J, et al. The Protective Effect of Dietary Phytosterols on Cancer Risk: A Systematic Meta-Analysis. Journal of Oncology. 2019.
[22] von Holtz RL, Fink CS, Awad AB. beta-Sitosterol activates the sphingomyelin cycle and induces apoptosis in LNCaP human prostate cancer cells. Nutr Cancer. 1998;32(1):8-12.
[23] Awad AB, Fink CS. Phytosterols as Anticancer Dietary Components: Evidence and Mechanism of Action. The Journal of Nutrition. 2000, Vol 130, Issue 9, pp 2127–2130.
[24] Woyengo T, Ramprasath V, Jones P. Anticancer effects of phytosterols. Eur J Clin Nutr. 2009, 63, 813–820.
[25] Rakel D. Benign Prostatic Hyperplasia, Chapter 60, Integrative Medicine (Fourth Edition).
Elsevier. 2018, pp 601-607.e1.
[26] Ward AB, Mir H, Kapur N, Gales DN, Carriere PP, Singh S. Quercetin inhibits prostate cancer by attenuating cell survival and inhibiting anti-apoptotic pathways. World J Surg Oncol. 2018;16(1):108.
[27] Yang F, Song L, Wang H, Wang J, Xu Z and Xing N. Quercetin in prostate cancer: Chemotherapeutic and chemopreventive effects, mechanisms and clinical application potential (Review). Oncol Rep. 2015, 33: 2659-2668.
[28] Tang SM, Deng XT, Zhou J, et al. Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects. Biomedicine & Pharmacotherapy. 2020, Vol 121.
[29] Xing N, Chen Y, Mitchell SH, Young CYF. Quercetin inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells. Carcinogenesis. 2001, Vol 22, Issue 3, pp 409–414.
[30] Zhang X, Huang J, Yu C, Xiang L, Li L, Shi D, Lin F. Quercetin Enhanced Paclitaxel Therapeutic Effects Towards PC-3 Prostate Cancer Through ER Stress Induction and ROS Production. Onco Targets Ther. 2020;13:513-523.
[31] Wilt T, Ishani A, Mac Donald R, Rutks I, Stark G. Pygeum africanum for benign prostatic hyperplasia. Cochrane Database Syst Rev. 2002;1998(1):CD001044.
[32] Andro MC, Riffaud JP. Pygeum africanum extract for the treatment of patients with benign prostatic hyperplasia: A review of 25 years of published experience. Current Therapeutic Research. 1995, Vol56, Issue 8, pp 796-817.
[33] Ishani A, MacDonald R, Nelson D, Rutks I, Wilt TJ, MD, MPH . Pygeum africanum for the treatment of patients with benign prostatic hyperplasia: a systematic review and quantitative meta-analysis. The American Journal of Medicine. 2000, Vol 109, Issue 8, P654-664.
[34] Gu Z, Suburu J, Chen H, Chen YQ. Mechanisms of omega-3 polyunsaturated fatty acids in prostate cancer prevention. BioMed research international. 2013;2013.
[35] Moussa H, Nguile-Makao M, Robitaille K, Guertin MH, Allaire J, Pelletier JF, Moreel X, Gevariya N, Diorio C, Desmeules P, Têtu B. Omega-3 fatty acids survey in men under active surveillance for prostate cancer: from intake to prostate tissue level. Nutrients. 2019 Jul 16;11(7):1616.
[36] Karunasinghe N. Zinc in Prostate Health and Disease: A Mini Review. Biomedicines. 2022 Dec 10;10(12):3206.
[37] Costello LC, Franklin RB. A comprehensive review of the role of zinc in normal prostate function and metabolism; and its implications in prostate cancer. Archives of biochemistry and biophysics. 2016 Dec 1;611:100-12.
[38] Stacewicz-Sapuntzakis M, Bowen PE. Role of lycopene and tomato products in prostate health. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 2005 May 30;1740(2):202-5.
[39] Wertz K. Lycopene effects contributing to prostate health. Nutrition and cancer. 20
[40] Kroeger N, Belldegrun AS, Pantuck AJ. Pomegranate extracts in the management of men's urologic health: scientific rationale and preclinical and clinical data. Evidence-based Complementary and Alternative Medicine: eCAM. 2013;2013.
[41] Wang L, Ho J, Glackin C, Martins-Green M. Specific pomegranate juice components as potential inhibitors of prostate cancer metastasis. Translational oncology. 2012 Oct 1;5(5):344-IN5.
[42] Nomikos T, Gioti K, Tsoukala M, Tenta R. Pumpkin seed extracts inhibit proliferation and induce autophagy in PC-3 androgen insensitive prostate cancer cells. Journal of Medicinal Food. 2021 Oct 1;24(10):1076-82.
[43] Leibbrand M, Siefer S, Schön C, Perrinjaquet-Moccetti T, Kompek A, Csernich A, Bucar F, Kreuter MH. Effects of an oil-free hydroethanolic pumpkin seed extract on symptom frequency and severity in men with benign prostatic hyperplasia: a pilot study in humans. Journal of medicinal food. 2019 Jun 1;22(6):551-9.
[44] Macoska JA. The use of beta-sitosterol for the treatment of prostate cancer and benign prostatic hyperplasia. American Journal of Clinical and Experimental Urology. 2023;11(6):467.
[45] Wilt TJ, Ishani A, MacDonald R, Stark G, Mulrow CD, Lau J, Cochrane Urology Group. Beta‐sitosterols for benign prostatic hyperplasia. Cochrane database of systematic reviews. 1996 Sep 1;2011(5).
[46] Quiles JL, Farquharson AJ, Simpson DK, Grant I, Wahle KW. Olive oil phenolics: effects on DNA oxidation and redox enzyme mRNA in prostate cells. British Journal of Nutrition. 2002 Sep;88(3):225-34.
[47] Acquaviva R, Di Giacomo C, Sorrenti V, Galvano F, Santangelo R, Cardile V, Gangia S, D'Orazio N, Abraham NG, Vanella L. Antiproliferative effect of oleuropein in prostate cell lines. International journal of oncology. 2012 Jul 1;41(1):31-8.
[48] Demark-Wahnefried W, Polascik TJ, George SL, Switzer BR, Madden JF, Ruffin IV MT, Snyder DC, Owzar K, Hars V, Albala DM, Walther PJ. Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery. Cancer Epidemiology Biomarkers & Prevention. 2008 Dec 1;17(12):3577-87.
[49] Demark-Wahnefried W, Price DT, Polascik TJ, Robertson CN, Anderson EE, Paulson DF, Walther PJ, Gannon M, Vollmer RT. Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features. Urology. 2001 Jul 1;58(1):47-52.
[50] Lee SW, Liong ML, Yuen KH, Leong WS, Chee C, Cheah PY, Choong WP, Wu Y, Khan N, Choong WL, Yap HW. Acupuncture versus sham acupuncture for chronic prostatitis/chronic pelvic pain. The American journal of medicine. 2008 Jan 1;121(1):79-e1.
[51] Zhang W, Ma L, Bauer BA, Liu Z, Lu Y. Acupuncture for benign prostatic hyperplasia: a systematic review and meta-analysis. PloS one. 2017 Apr 4;12(4):e0174586.
[52] Pathak SD, Rajbhoj PH, Bhogal RS. Effect of a yoga module on an enlarged prostate in elderly patients: Two case studies. Yoga Mimamsa. 2017 Jan 1;49(1):34-9.
[53] Ben-Josef AM, Wileyto EP, Chen J, Vapiwala N. Yoga intervention for patients with prostate cancer undergoing external beam radiation therapy: A pilot feasibility study. Integrative cancer therapies. 2016 Sep;15(3):272-8.
[54] Shoorabeh FF, Dabidiroshan V, Saraf BS, Nuri R. Investigating the effects of regular resistance training and prostatic massage on proinflammatory markers and serum prostate-specific antigen levels in males with prostate cancer. Middle East Journal of Rehabilitation and Health. 2016 Jan 1;3(1).
[55] Wilk I, Kassolik K, Kołodyńska G, Nowak B, Piotrów P, Andrzejewski W. The use of therapeutic massage in benign prostatic hyperplasia: a case study. Medical Science Pulse. 2023 Jun 3;17(2):38-44.
[56] Perez FS, Rosa NC, Da Rocha AF, Peixoto LR, Miosso CJ. Effects of biofeedback in preventing urinary incontinence and erectile dysfunction after radical prostatectomy. Frontiers in oncology. 2018 Feb 26;8:20.
[57] Potts JM. Alternative approaches to the management of prostatitis: biofeedback, progressive relaxation and the concept of functional somatic syndromes. European Urology Supplements. 2003 Mar 1;2(2):34-7.
1. Magnesium: Magnesium supports hormonal balance and reduces inflammation, contributing to overall tissue health. Its role in cellular integrity and maintaining long-term function makes it crucial for wellness.
2. Zinc: Zinc regulates cell growth and supports immune function, helping maintain tissue integrity. Adequate zinc levels may also reduce risks associated with glandular changes and discomfort.
3. Omega 3: Omega-3 fatty acids lower inflammation and oxidative stress, supporting long-term wellness and comfort. Their protective effects on cells help maintain normal function and may reduce discomfort.
1. Stinging Nettle Extract: Stinging nettle helps reduce fluid retention and improve urinary flow, contributing to comfort. Its role in lowering markers of swelling supports long-term wellness and function.
2. Green Tea Extract: Green tea supports hormone balance and reduces inflammation through its rich antioxidant content. It helps protect cells from oxidative damage and promotes comfort, making it beneficial for long-term wellness.
3. Saw Palmetto Extract: Saw palmetto supports urinary function by helping reduce swelling and discomfort. Its effects on fluid balance contribute to improved well-being and long-term function.
4. Plant Sterols: Plant sterols help regulate hormone levels, promoting normal cellular function. By supporting long-term tissue integrity and fluid balance, they contribute to overall comfort and wellness.
5. Quercetin: Quercetin reduces inflammation and supports normal cell growth by promoting the removal of abnormal cells. Its antioxidant properties contribute to comfort and long-term well-being.
6. Bromelain: Bromelain helps improve the absorption of quercetin while offering its own anti-inflammatory benefits. This synergistic effect contributes to better overall cellular health and long-term wellness.
7. African Cherry: African cherry reduces fluid retention and improves urinary comfort, promoting long-term wellness. Traditionally used for swelling, it supports tissue function and enhances overall comfort.
8. Curcumin: Curcumin promotes the natural elimination of abnormal cells and reduces inflammation, supporting long-term wellness. Its effects on cellular health make it essential for maintaining comfort and function.
9. Lycopene: Lycopene helps maintain normal cell function by reducing oxidative stress and inflammation. Its antioxidant properties contribute to tissue integrity and long-term wellness, making it an essential component of a balanced diet.
10. Pomegranate Extract: Pomegranate helps maintain tissue integrity by reducing inflammation and oxidative stress. Its rich antioxidant profile supports long-term wellness and promotes overall comfort and function.
11. Pumpkin Seed Oil: Pumpkin seed supports urinary function by promoting fluid balance and reducing discomfort. Its benefits extend to long-term tissue health, making it a key contributor to overall well-being.
12. Sterols: Beta-sitosterol regulates hormone levels and supports fluid balance, helping reduce discomfort. Its benefits for overall wellness extend to maintaining proper tissue function and promoting long-term health.
1. Olive Oil: Extra virgin olive oil helps manage inflammation and oxidative stress, supporting long-term tissue integrity. Its monounsaturated fats and polyphenols contribute to wellness and overall comfort.
2. Flaxseed Oil: Flaxseed, including flaxseed flour and oil, helps regulate hormone levels and reduce inflammation. Its benefits for tissue integrity and fluid balance contribute to long-term comfort and overall wellness.
1. Acupuncture: Acupuncture targets key points such as CV4 (Guanyuan) below the navel and SP6 (Sanyinjiao) above the inner ankle to improve bladder function and circulation. This helps alleviate urinary issues and reduce inflammation, offering relief for men experiencing BPH.
2. Yoga: Yoga poses like the seated forward bend promote pelvic circulation and reduce inflammation. Regular practice helps manage urinary symptoms, reduces stress, and supports hormonal balance.
3. Massage Therapy: Massage therapy, particularly prostate massage, enhances fluid circulation, reducing inflammation and discomfort. This technique improves urinary flow, alleviates pain, and supports overall prostate function.
4. Biofeedback: Biofeedback helps men control pelvic floor muscles, improving urinary flow and relieving pain in cases of prostatitis. It aids muscle relaxation and coordination, contributing to reduced discomfort and better bladder function.
Supplements
Plant Extracts
Natural Compounds
Alternative Treatments
Symptoms & Signs
Causes
Not Applicable
Books That You May Want To Read
How Nutrients Function
Antioxidants: Antioxidants protect cells from oxidative stress caused by free radicals, potentially reducing the risk of chronic diseases such as cancer and cardiovascular ailments. They safeguard DNA integrity, slow down aging processes, and support overall cellular health.
Enzymes and Coenzymes: Enzymes catalyze biochemical reactions, while coenzymes assist in these processes by binding temporarily to enzymes. Together, they regulate digestion, energy production, immune responses, and various metabolic pathways.
Fatty Acids: Fatty acids serve as energy sources, structural components of cell membranes, and precursors to signaling molecules. Essential fatty acids, like omega-3 and omega-6, play critical roles in brain function, cardiovascular health, and inflammation regulation.
Fruit Extracts: Rich in antioxidants, vitamins, and fiber, fruit extracts offer numerous health benefits, including anti-inflammatory, anti-cancer, and immune-boosting properties. They also support digestive health and contribute to overall well-being.
Herbal Extracts: Herbal extracts contain bioactive compounds with various medicinal properties, including antioxidant, anti-inflammatory, and antimicrobial effects. They have been used traditionally to support digestion, immunity, and overall health.
Minerals: Minerals are essential for various physiological functions, including bone health, nerve transmission, and enzyme activity. They support overall health by ensuring proper cellular function and metabolic processes.
Nutrients Explained In Nutritional Guide
Podcast Episodes To Listen To
Educational Videos To Learn From
Functional Lab Tests That You Might Consider
References
Things To Do
Dietary recommendations that support prostate health include:
a whole-foods-based diet consisting of fresh vegetables, fruits, meat, fish, legumes, whole grains, and healthy fats.
consume a high-fiber diet to support proper metabolism, weight, and cholesterol levels.
whole foods high in zinc. Zinc is necessary for the proper functioning of the prostate gland.
whole foods rich in selenium. Selenium helps maintain proper function and has cancer-protective properties.
whole foods rich in copper. Copper has anti-cancer properties.
phytosterols found in plant-based whole foods. Phytosterols help regulate cholesterol levels and diminish the swelling of the prostate.
opt for organic, grass-fed, pasture-raised whole foods.
antioxidants from whole foods. Antioxidants, such as lycopene, help protect the prostate from cancer.
Anti-inflammatory compounds, such as curcumin, anthocyanins, omega-3 fatty acids, sulforaphane, carotenoids, tocopherols, vitamin C, quercetin, etc. They reduce inflammation and help protect against disease.
Drink quality mineral water, herbal tea, and green tea. Green contains a powerful antioxidant called epigallocatechin gallate [EGCG].
Furthermore, try the following:
regular physical activity. It helps reduce the risk of the prostate becoming enlarged.
maintain a healthy weight. Excessive abdominal fat is considered a risk factor for having an enlarged prostate.
maintain healthy cholesterol levels. The prostate gland produces and stores cholesterol. Therefore, maintaining a healthy cholesterol metabolism and cholesterol levels will enable it to perform its functions correctly.
get quality sleep every night.
practice stress reduction techniques through yoga, mindfulness, and meditation.
intermittent fasting. It helps reduce inflammation and oxidative stress and regulates cholesterol levels.
have regular sexual intercourse to encourage proper circulation and prostate function.
Wear loose underwear.
Things To Avoid
For prostate health, avoid the following:
processed, junk, and fast foods. They are known to elevate cholesterol levels, increase weight, and lead to inflammation and oxidative stress.
sugar. Sugar is inflammatory and damaging to metabolic health.
refined carbohydrates, which may increase your risk of developing prostate conditions.
trans fatty acids, which contribute to the development of prostate cancer.
meats contaminated by the use of hormones, antibiotics, and steroids. They all contribute to an increased risk of prostate complications.
added sodium. Processed and packaged foods contain excessive amounts of sodium. Added sodium is implicated in the development of prostate enlargement.
alcohol. Excessive alcohol consumption contributes to the development of cancer.
avoid dietary exposure to heavy metals, pesticides, and other pollutants. Some of them are carcinogenic.
In addition, avoid the following:
weight gain, becoming obese, and becoming metabolically unhealthy. High cholesterol levels contribute to prostate health problems.
sedentary lifestyle and lack of physical activity. Sitting for prolonged periods of time puts a lot of pressure on the prostate.
smoking. It causes inflammation and has a negative impact on general health.
chronic stress.
social isolation, which can contribute to poor mental health.