Neuropathic Pain
Description
Body System
[1] Sánchez-Ramírez GM, Caram-Salas NL, Rocha-González HI, et al. Benfotiamine relieves inflammatory and neuropathic pain in rats. Eur J Pharmacol. 2006;530(1-2):48-53.
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[34] Hesselink JM, Hekker TA. Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series. Journal of Pain Research. 2012 Oct 26:437-42.
[35] Banafshe HR, Hamidi GA, Noureddini M, Mirhashemi SM, Mokhtari R, Shoferpour M. Effect of curcumin on diabetic peripheral neuropathic pain: possible involvement of opioid system. European journal of pharmacology. 2014 Jan 15;723:202-6.
[36] Li Y, Zhang Y, Liu DB, Liu HY, Hou WG, Dong YS. Curcumin attenuates diabetic neuropathic pain by downregulating TNF-α in a rat model. International journal of medical sciences. 2013;10(4):377.
[37] Du C, Xiao Z, Yijia G, Jingfeng Y. A network-based pharmacologic investigation of the mechanism of action of frankincense-myrrh in the treatment of painful diabetic peripheral neuropathy. molecular pharmacology. 2023 Oct 20;5(10):82-91.
[38] Liao Y, Guo C, Wen A, Bai M, Ran Z, Hu J, Wang J, Yang J, Ding Y. Frankincense-Myrrh treatment alleviates neuropathic pain via the inhibition of neuroglia activation mediated by the TLR4/MyD88 pathway and TRPV1 signaling. Phytomedicine. 2023 Jan 1;108:154540.
[39] Kuai CP, Ju LJ, Hu PP, Huang F. Corydalis saxicola alkaloids attenuate cisplatin-induced neuropathic pain by reducing loss of IENF and blocking TRPV1 activation. The American Journal of Chinese Medicine. 2020 Mar 5;48(02):407-28.
[40] Choi JG, Kang SY, Kim JM, Roh DH, Yoon SY, Park JB, Lee JH, Kim HW. Antinociceptive effect of cyperi rhizoma and corydalis tuber extracts on neuropathic pain in rats. The Korean Journal of Physiology & Pharmacology. 2012 Dec;16(6):387-92.
[41] Derry S, Rice AS, Cole P, Tan T, Moore RA. Topical capsaicin (high concentration) for chronic neuropathic pain in adults. Cochrane Database of Systematic Reviews. 2017(1).
[42] Sultana A, Singla RK, He X, Sun Y, Alam MS, Shen B. Topical capsaicin for the treatment of neuropathic pain. Current Drug Metabolism. 2021 Mar 1;22(3):198-207.
[43] Park HJ, Lee HG, Kim YS, Lee JY, Jeon JP, Park C, Moon DE. Ginkgo biloba extract attenuates hyperalgesia in a rat model of vincristine-induced peripheral neuropathy. Anesthesia & Analgesia. 2012 Nov 1;115(5):1228-33.
[44] Kim YS, Park HJ, Kim TK, Moon DE, Lee HJ. The effects of Ginkgo biloba extract EGb 761 on mechanical and cold allodynia in a rat model of neuropathic pain. Anesthesia & Analgesia. 2009 Jun 1;108(6):1958-63.
[45] Galeotti N, Vivoli E, Bilia AR, Vincieri FF, Ghelardini C. St. John's Wort reduces neuropathic pain through a hypericin-mediated inhibition of the protein kinase C γ and ɛ activity. Biochemical pharmacology. 2010 May 1;79(9):1327-36.
[46] Galeotti N, Maidecchi A, Mattoli L, Burico M, Ghelardini C. St. John's Wort seed and feverfew flower extracts relieve painful diabetic neuropathy in a rat model of diabetes. Fitoterapia. 2014 Jan 1;92:23-33.
[47] Tao L, Ding Q, Gao C, Sun X. Resveratrol attenuates neuropathic pain through balancing pro-inflammatory and anti-inflammatory cytokines release in mice. International Immunopharmacology. 2016 May 1;34:165-72.
[48] Xu M, Cheng Z, Ding Z, Wang Y, Guo Q, Huang C. Resveratrol enhances IL-4 receptor-mediated anti-inflammatory effects in spinal cord and attenuates neuropathic pain following sciatic nerve injury. Molecular pain. 2018 Mar;14:1744806918767549.
[49] Xu DH, Cullen BD, Tang M, Fang Y. The effectiveness of topical cannabidiol oil in symptomatic relief of peripheral neuropathy of the lower extremities. Current pharmaceutical biotechnology. 2020 Apr 1;21(5):390-402.
[50] Serpell M, Ratcliffe S, Hovorka J, Schofield M, Taylor L, Lauder H, Ehler E. A double‐blind, randomized, placebo‐controlled, parallel group study of THC/CBD spray in peripheral neuropathic pain treatment. European journal of pain. 2014 Aug;18(7):999-1012.
[51] Rivaz M, Rahpeima M, Khademian Z, Dabbaghmanesh MH. The effects of aromatherapy massage with lavender essential oil on neuropathic pain and quality of life in diabetic patients: A randomized clinical trial. Complementary Therapies in Clinical Practice. 2021 Aug 1;44:101430.
[52] Abdel Hamid Hawash M, Gamal Ramadan Asal M, Ramadan Shaheen Ibrahim S. Effect of Aromatherapy Massage with Chamomile Oil versus Lavender Oil on Neuropathic Pain and Quality of Life in Diabetic Patients: randomized controlled clinical trial. Egyptian Journal of Health Care. 2023 Jun 1;14(2):724-37.
[53] Melo Júnior JD, Damasceno MD, Santos SA, Barbosa TM, Araújo JR, Vieira-Neto AE, Wong DV, Lima-Júnior RC, Campos AR. Acute and neuropathic orofacial antinociceptive effect of eucalyptol. Inflammopharmacology. 2017 Apr;25:247-54.
[54] Gok Metin Z, Arikan Donmez A, Izgu N, Ozdemir L, Arslan IE. Aromatherapy massage for neuropathic pain and quality of life in diabetic patients. Journal of Nursing Scholarship. 2017 Jul;49(4):379-88.
[55] Yaksh TL. Calcium channels as therapeutic targets in neuropathic pain. The Journal of Pain. 2006 Jan 1;7(1):S13-30.
[56] Cui W, Wu H, Yu X, Song T, Xu X, Xu F. The calcium channel α2δ1 subunit: Interactional targets in primary sensory neurons and role in neuropathic pain. Frontiers in Cellular Neuroscience. 2021 Sep 30;15:699731.
[57] Ma X, Chen W, Yang NN, Wang L, Hao XW, Tan CX, Li HP, Liu CZ. Potential mechanisms of acupuncture for neuropathic pain based on somatosensory system. Frontiers in neuroscience. 2022 Sep 20;16:940343.
[58] Ju Z, Cui H, Guo X, Yang H, He J, Wang K. Molecular mechanisms underlying the effects of acupuncture on neuropathic pain. Neural Regeneration Research. 2013 Sep 5;8(25):2350-9.
[59] Mokhtari T, Ren Q, Li N, Wang F, Bi Y, Hu L. Transcutaneous electrical nerve stimulation in relieving neuropathic pain: basic mechanisms and clinical applications. Current pain and headache reports. 2020 Apr;24:1-4.
[60] Celik EC, Erhan B, Gunduz B, Lakse E. The effect of low-frequency TENS in the treatment of neuropathic pain in patients with spinal cord injury. Spinal cord. 2013 Apr;51(4):334-7.
[61] Norrbrink C, Lundeberg T. Acupuncture and massage therapy for neuropathic pain following spinal cord injury: an exploratory study. Acupuncture in Medicine. 2011 Jun;29(2):108-15.
[62] Mohammed AS, Hassanein SM, Soliman FM, Elsheimy HA. Effect of Aromatherapy Massage on Neuropathic Pain Among Patients with Type II Diabetes Mellitus. International Journal of Novel Research in Healthcare and Nursing. 2019;6(3):1077-86.
[63] Campo AR, Pacichana-Quinayáz SG, Bonilla-Escobar FJ, Leiva-Pemberthy LM, Tovar-Sánchez MA, Hernández-Orobio OM, Arango-Hoyos GP, Mujanovic A. Effectiveness of Hydrotherapy on Neuropathic Pain and Pain Catastrophization in Patients With Spinal Cord Injury: Protocol for a Pilot Trial Study. JMIR research protocols. 2022 Apr 29;11(4):e37255.
[64] Shourabi P, Bagheri R, Ashtary-Larky D, Wong A, Motevalli MS, Hedayati A, Baker JS, Rashidlamir A. Effects of hydrotherapy with massage on serum nerve growth factor concentrations and balance in middle aged diabetic neuropathy patients. Complementary therapies in clinical practice. 2020 May 1;39:101141.
[65] Telles S, Sayal N, Nacht C, Chopra A, Patel K, Wnuk A, Dalvi P, Bhatia K, Miranpuri G, Anand A. Yoga: Can it be integrated with treatment of neuropathic pain?. Annals of neurosciences. 2019 Apr;26(2):82-91.
[66] Bhardwaj P, Ahuja N, Parchani A, Singh S, Sethi D, Pathania M. Yoga as a complementary therapy in neuropathic pain: A systematic review and meta-analysis of randomized controlled trials. Journal of Family Medicine and Primary Care. 2023 Oct 1;12(10):2214-22.
[67] Li L, Manor B. Long term Tai Chi exercise improves physical performance among people with peripheral neuropathy. The American journal of Chinese medicine. 2010;38(03):449-59.
[68] Ahn S, Song R. Effects of tai chi exercise on glucose control, neuropathy scores, balance, and quality of life in patients with type 2 diabetes and neuropathy. The Journal of Alternative and Complementary Medicine. 2012 Dec 1;18(12):1172-8.
[69] Gevers‐Montoro C, Provencher B, Descarreaux M, Ortega de Mues A, Piché M. Neurophysiological mechanisms of chiropractic spinal manipulation for spine pain. European Journal of Pain. 2021 Aug;25(7):1429-48.
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[71] Gu N, Niu JY, Liu WT, Sun YY, Liu S, Lv Y, Dong HL, Song XJ, Xiong LZ. Hyperbaric oxygen therapy attenuates neuropathic hyperalgesia in rats and idiopathic trigeminal neuralgia in patients. European Journal of Pain. 2012 Sep;16(8):1094-105.
[72] Liu YD, Wang ZB, Han G, Zhao P. Hyperbaric oxygen treatment attenuates neuropathic pain by elevating autophagy flux via inhibiting mTOR pathway. American Journal of Translational Research. 2017;9(5):2629.
1. Benfotiamine: Benfotiamine provides antioxidant protection and reduces inflammation, helping to combat oxidative stress that damages nerves. Its role in modulating nerve cell function makes it effective in alleviating nerve pain and improving nerve health.
2. Alpha Lipoic Acid: Alpha lipoic acid is a powerful antioxidant that stimulates nerve regeneration and protects nerve fibers from oxidative stress. Its ability to prevent further damage helps alleviate chronic pain and supports nerve function.
3. Omega 3: Omega-3 fatty acids offer neuroprotective benefits by reducing inflammation and promoting nerve regeneration, particularly demonstrated in experimental models. These effects help minimize nerve damage, supporting recovery and reducing pain symptoms.
4. Vitamin B Complex: Vitamin B complex supports nerve health by addressing multiple pathways. Vitamin B12 aids in nerve regeneration, while B6 and B1 reduce inflammation and protect nerve fibers, collectively helping reduce nerve pain and improve function.
5. Acetyl-L-Carnitine [ALC]: Acetyl-L-Carnitine helps repair nerve cells and boosts energy production in nerve mitochondria. Its neuroprotective properties make it particularly useful in reducing pain linked to diabetic and chemotherapy-induced neuropathy.
6. Magnesium: Magnesium reduces nerve excitability by blocking NMDA receptors, which helps prevent pain signals from being sent. It also stabilizes nerve activity, alleviating burning sensations and pain associated with neuropathy.
7. N-Acetyl-L-Cysteine [NAC]: N-acetyl-L-cysteine (NAC) increases glutathione levels, a potent antioxidant, to protect nerves from oxidative stress. By reducing inflammation, NAC helps prevent further nerve damage and improves symptoms of chronic pain.
8. Palmitoylethanolamide [PEA]: Palmitoylethanolamide (PEA) is a naturally occurring fatty acid that calms neuroinflammation and modulates the immune response. It effectively reduces pain by lowering inflammation in nerve tissues and supporting long-term pain relief.
9. Calcium: Calcium regulates nerve signaling and muscle control. Balanced calcium levels help reduce nerve hypersensitivity and prevent cramps, playing a crucial role in managing nerve pain and supporting overall muscle function.
1. Borage Oil: Borage oil, rich in gamma-linolenic acid (GLA), helps reduce inflammation and improves nerve function, making it effective in alleviating pain, tingling, and numbness associated with diabetic and peripheral neuropathy.
2. Evening Primrose Oil: Evening primrose oil contains gamma-linolenic acid (GLA), which has been shown to reduce inflammation and relieve nerve pain. It helps improve nerve function and is beneficial for managing symptoms like tingling and burning sensations.
3. Curcumin: Curcumin offers potent anti-inflammatory and antioxidant effects, which help protect nerves from further damage. By promoting nerve regeneration, curcumin reduces pain and improves overall nerve health.
4. Boswellia Serrata Extract: Boswellia serrata has powerful anti-inflammatory properties that reduce nerve inflammation. It helps alleviate pain associated with conditions like diabetic neuropathy by targeting the root cause of nerve damage.
5. Corydalis Extract: Corydalis reduces nerve pain by acting on dopamine receptors without causing sedation. It is particularly useful for managing chronic nerve pain, including sciatica, by modulating how the brain perceives pain signals.
6. Cayenne Pepper Extract: Capsaicin, an anctive compound of cayenne, desensitizes nerve endings by reducing substance P, a neurotransmitter involved in pain signaling. Its topical use is effective in treating chronic conditions like postherpetic neuralgia and diabetic neuropathy.
7. Ginkgo Biloba Extract: Ginkgo biloba improves circulation to damaged nerves and provides antioxidant protection. These effects help reduce pain, tingling, and numbness, supporting overall nerve health and function.
8. St. John’s Wort Extract: St. John’s wort modulates neurotransmitters like serotonin, helping to alleviate nerve pain. Its calming effect on the nervous system makes it useful for managing conditions like sciatica and neuropathy.
9. Resveratrol: Resveratrol reduces inflammation and oxidative stress, which are common in neuropathic conditions. By promoting nerve repair, it helps alleviate pain and improve nerve function, particularly in diabetic neuropathy.
10. Lavender Essential Oil: Lavender essential oil provides analgesic and anti-inflammatory benefits that calm pain receptors and improve circulation. These effects help reduce nerve pain and discomfort, while also easing anxiety associated with chronic pain.
11. Eucalyptus Essential Oil: Eucalyptus essential oil offers anti-inflammatory and analgesic benefits that improve circulation and reduce nerve inflammation. It is effective in managing nerve pain conditions like neuropathy and neuralgia.
12. Frankincense Essential Oil: Frankincense essential oil offers strong anti-inflammatory effects that help reduce nerve inflammation and pain. Its use is beneficial in managing conditions like diabetic neuropathy by promoting nerve healing and reducing discomfort.
1. Nutritional Yeast: Nutritional yeast, rich in essential B vitamins like B12, B1, and B6, serves as an alternative to a traditional vitamin B complex. These vitamins help promote myelination, reduce inflammation, and protect nerve endings, offering relief from pain in neuropathic conditions.
2. CBD Oil: CBD oil interacts with the endocannabinoid system to reduce neuroinflammation and modulate pain signals. This helps relieve chronic nerve pain and hypersensitivity, providing significant relief by influencing pain perception pathways.
1. Acupuncture: Acupuncture helps reduce nerve pain by stimulating specific points such as LI4 (Hegu), located between the thumb and index finger, and GV3 (Yaoyangguan), located on the lower back. These points improve energy flow, reduce inflammation, and support nerve health.
2. Cryotherapy: Cryotherapy exposes the body to cold temperatures, reducing inflammation and numbing pain receptors. This helps decrease nerve sensitivity and alleviate discomfort in chronic neuropathic conditions.
3. Transcutaneous Electrical Nerve Stimulation [TENS]: TENS therapy uses mild electrical impulses to block pain signals and stimulate endorphin release. This therapy effectively reduces nerve pain by modulating pain pathways and improving nerve function.
4. Massage Therapy: Massage therapy reduces muscle tension and improves blood flow to damaged nerves, helping to relieve pain and discomfort. Regular massages enhance circulation, promoting better nerve health and recovery.
5. Hydrotherapy: Hydrotherapy uses water’s buoyancy and heat to reduce pain and promote circulation. Warm water baths help soothe nerve pain and inflammation, making it beneficial for managing neuropathic symptoms.
6. Yoga: Yoga combines stretches, breathing exercises, and relaxation techniques to improve flexibility and reduce pain. Regular practice supports nerve health and helps alleviate the pain associated with chronic conditions.
7. Tai Chi: Tai chi incorporates slow, mindful movements and deep breathing to enhance balance, reduce pain, and improve overall well-being. This gentle exercise helps alleviate nerve pain by promoting relaxation and reducing stress.
8. Chiropractic Care: Chiropractic therapy focuses on spinal adjustments to improve alignment and reduce nerve irritation. By addressing misalignments, this therapy helps alleviate nerve pain and supports spinal health.
9. Hyperbaric Chamber Therapy: Hyperbaric chamber therapy enhances oxygen delivery to damaged nerves by increasing pressure in a pure oxygen environment. This therapy promotes healing, reduces inflammation, and alleviates pain associated with neuropathic conditions.
Supplements
Plant Extracts
Natural Compounds
Alternative Treatments
Symptoms & Signs
Causes
Injury, Poor Blood Supply To the Brain, Nutritional Deficiencies, Alcohol Use, Medications
Books That You May Want To Read
How Nutrients Function
Amino Acids: Amino acids serve as the building blocks of proteins, crucial for muscle growth and repair. Additionally, they play key roles in maintaining proper pH levels, storing nitrogen, synthesizing hormones, and facilitating enzymatic reactions.
Antioxidants: Antioxidants protect cells from oxidative stress caused by free radicals, potentially reducing the risk of chronic diseases such as cancer and cardiovascular ailments. They safeguard DNA integrity, slow down aging processes, and support overall cellular health.
Fatty Acids: Fatty acids serve as energy sources, structural components of cell membranes, and precursors to signaling molecules. Essential fatty acids, like omega-3 and omega-6, play critical roles in brain function, cardiovascular health, and inflammation regulation.
Herbal Extracts: Herbal extracts contain bioactive compounds with various medicinal properties, including antioxidant, anti-inflammatory, and antimicrobial effects. They have been used traditionally to support digestion, immunity, and overall health.
Minerals: Minerals are essential for various physiological functions, including bone health, nerve transmission, and enzyme activity. They support overall health by ensuring proper cellular function and metabolic processes.
Other Nutrients: Other nutrients encompass a wide array of essential compounds crucial for various physiological functions. This category includes neurotransmitters and their precursors, which facilitate nerve signaling and are vital for central nervous system function. Additionally, naturally occurring structural components and biological detergents, such as phospholipids and bile salts, play critical roles in tissue repair, fat digestion, and overall bodily function. Phospholipids contribute to cell membrane integrity and fat emulsification, while bile salts are key to digesting and absorbing dietary fats. Hormones and their precursors regulate numerous physiological processes, including metabolism, growth, and reproduction. Furthermore, naturally occurring chemicals and metals play pivotal roles in enzymatic reactions, immune function, and overall health maintenance.
Vitamins: Vitamins are essential micronutrients that play diverse roles in supporting cellular processes, immune function, and overall health. They must be obtained through diet or supplementation to ensure proper bodily function.
Nutrients Explained In Nutritional Guide
Podcast Episodes To Listen To
Educational Videos To Learn From
Functional Lab Tests That You Might Consider
References
Things To Do
To better manage neuropathic pain, make sure to include the following:
a whole-foods-based diet consisting of fresh vegetables, fruit, meats, fish, legumes, whole grains, and healthy fats.
Vegetables and fruits are rich in antioxidants and anti-inflammatory compounds, which help counteract oxidative stress and inflammation.
A high-fiber diet helps control blood sugar levels.
Omega-3-rich foods, such as fatty fish, sea food, avocados, nuts, seeds, etc.
Include foods rich in vitamin B12, such as organ meats, fatty fish, beef, dairy products, milk, eggs, etc. Vitamin B12 can help regenerate damaged tissues.
Incorporate foods containing vitamin B1, such as fish, meats, whole grains, etc. Thiamine is known to reduce inflammation and pain.
Include foods rich in vitamin B6, such as liver, fatty fish, poultry, dark leafy greens, bananas, etc. It helps protect nerve endings.
Consume foods rich in vitamin D, such as fatty fish, eggs, mushrooms, etc. It protects the neurons from degeneration.
Strengthen your gut microbiome by including prebiotic and probiotic foods. A healthy gut can modulate the immune signaling related to neuropathy.
stay hydrated. Drink quality mineral water and implement an electrolyte formula to balance your electrolyte levels.
Also, do the following:
a light-intensity exercise, such as yoga, that is suitable for your condition.
maintain a healthy weight.
maintain healthy blood glucose levels.
Get quality sleep that supports regeneration.
practice stress reduction techniques, such as yoga, meditation, and mindfulness. Stress can add to your symptoms and make your condition worse.
minimize your toxin exposure, both from food and daily items.
Things To Avoid
In neuropathic pain, avoid the following:
processed, deep-fried, junk, and fast foods that contribute to inflammation, gut dysbiosis, and elevated blood glucose levels.
refined grains and gluten, which cause spikes in blood sugar and may contribute to an increased pain sensation.
foods you are allergic to or intolerant of.
alcohol, which makes neuropathic pain worse.
caffeine, which is a stimulant for the nervous system.
sugar and artificial sweeteners. They are highly inflammatory and can make the condition worse.
trans fats that cause inflammation.
Furthermore, steer away from:
sedentary lifestyle.
becoming overweight or obese.
developing insulin resistance and diabetes.
toxins from food and the environment. They contribute to the occurrence of neuropathic pain.