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Essential4Health

Get Healthy ~ Stay Healthy

Essential4Health

Get Healthy ~ Stay Healthy

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INFLAMMATORY BOWEL DISEASE

Description

Inflammatory Bowel Disease (IBD) refers to a group of chronic inflammatory conditions affecting the digestive tract, with the most common forms being Crohn’s disease and ulcerative colitis. Individuals with IBD often experience a variety of symptoms, including fatigue, diarrhea, abdominal pain, cramps, blood in the stool, reduced appetite, and weight loss. IBD is typically caused by an autoimmune response, in which the body mistakenly attacks its own digestive tract, leading to persistent inflammation and damage. Over time, this inflammation can result in complications such as scarring, malabsorption, or even an increased risk of colorectal cancer. Early diagnosis and proper management are essential to reduce symptoms and improve quality of life. Treatment options usually involve medications to reduce inflammation and control the immune response, along with lifestyle and dietary changes. Regular medical monitoring is crucial for managing the condition and addressing flare-ups or complications effectively.

Body System

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[1] Silva JPB, Navegantes-Lima KC, Oliveira ALB, et al. Protective Mechanisms of Butyrate on Inflammatory Bowel Disease. Curr Pharm Des. 2018;24(35):4154-4166.
[2] Facchin S, Vitulo N, Calgaro M, et al. Microbiota changes induced by microencapsulated sodium butyrate in patients with inflammatory bowel disease. Neurogastroenterol Motil. 2020;32(10):e13914.
[3] Di Sabatino A, Morera R, Ciccocioppo R, et al. Oral butyrate for mildly to moderately active Crohn's disease. Aliment Pharmacol Ther. 2005;22(9):789-794.
[4] Zhou Z, Cao J, Liu X, Li M. Evidence for the butyrate metabolism as key pathway improving ulcerative colitis in both pediatric and adult patients. Bioengineered. 2021;12(1):8309-8324.
[5] Effenberger M, Reider S, Waschina S, et al. Microbial Butyrate Synthesis Indicates Therapeutic Efficacy of Azathioprine in IBD Patients. J Crohns Colitis. 2021;15(1):88-98.
[6] Dou X, Gao N, Yan D, Shan A. Sodium Butyrate Alleviates Mouse Colitis by Regulating Gut Microbiota Dysbiosis. Animals (Basel). 2020;10(7):1154. Published 2020 Jul 7.
[7] Geirnaert A, Calatayud M, Grootaert C, et al. Butyrate-producing bacteria supplemented in vitro to Crohn's disease patient microbiota increased butyrate production and enhanced intestinal epithelial barrier integrity. Sci Rep. 2017;7(1):11450. Published 2017 Sep 13.
[8] Goulart RA, Barbalho SM, Lima VM, et al. Effects of the Use of Curcumin on Ulcerative Colitis and Crohn's Disease: A Systematic Review. J Med Food. 2021;24(7):675-685.
[9] Mazieiro R, Frizon RR, Barbalho SM, Goulart RA. Is Curcumin a Possibility to Treat Inflammatory Bowel Diseases?. J Med Food. 2018;21(11):1077-1085.
[10] Hanai H, Sugimoto K. Curcumin has bright prospects for the treatment of inflammatory bowel disease. Curr Pharm Des. 2009;15(18):2087-2094.
[11] Baliga MS, Joseph N, Venkataranganna MV, Saxena A, Ponemone V, Fayad R. Curcumin, an active component of turmeric in the prevention and treatment of ulcerative colitis: preclinical and clinical observations. Food Funct. 2012;3(11):1109-1117.
[12] Iqbal U, Anwar H, Quadri AA. Use of Curcumin in Achieving Clinical and Endoscopic Remission in Ulcerative Colitis: A Systematic Review and Meta-analysis. Am J Med Sci. 2018;356(4):350-356.
[13] Vecchi Brumatti L, Marcuzzi A, Tricarico PM, Zanin V, Girardelli M, Bianco AM. Curcumin and inflammatory bowel disease: potential and limits of innovative treatments. Molecules. 2014;19(12):21127-21153. Published 2014 Dec 16.
[14] Sugimoto K, Ikeya K, Bamba S, et al. Highly Bioavailable Curcumin Derivative Ameliorates Crohn's Disease Symptoms: A Randomized, Double-Blind, Multicenter Study. J Crohns Colitis. 2020;14(12):1693-1701.
[15] Cunha Neto F, Marton LT, de Marqui SV, Lima TA, Barbalho SM. Curcuminoids from Curcuma Longa: New adjuvants for the treatment of crohn's disease and ulcerative colitis?. Crit Rev Food Sci Nutr. 2019;59(13):2136-2143.
[16] Holt PR, Katz S, Kirshoff R. Curcumin therapy in inflammatory bowel disease: a pilot study. Dig Dis Sci. 2005;50(11):2191-2193.
[17] Gupta I, Parihar A, Malhotra P, et al. Effects of gum resin of Boswellia serrata in patients with chronic colitis. Planta Med. 2001;67(5):391-395.
[18] Gupta I, Parihar A, Malhotra P, et al. Effects of Boswellia serrata gum resin in patients with ulcerative colitis. Eur J Med Res. 1997;2(1):37-43.
[19] Gerhardt H, Seifert F, Buvari P, Vogelsang H, Repges R. Therapie des aktiven Morbus Crohn mit dem Boswellia-serrata-Extrakt H 15 [Therapy of active Crohn disease with Boswellia serrata extract H 15]. Z Gastroenterol. 2001;39(1):11-17.
[20] Ammon HP. Boswellic Acids and Their Role in Chronic Inflammatory Diseases. Adv Exp Med Biol. 2016;928:291-327.
[21] Catanzaro D, Rancan S, Orso G, et al. Boswellia serrata Preserves Intestinal Epithelial Barrier from Oxidative and Inflammatory Damage. PLoS One. 2015;10(5):e0125375. Published 2015 May 8.
[22] Tahan G, Aytac E, Aytekin H, et al. Vitamin E has a dual effect of anti-inflammatory and antioxidant activities in acetic acid-induced ulcerative colitis in rats. Can J Surg. 2011;54(5):333-338.
[23] Fabisiak N, Fabisiak A, Watala C, Fichna J. Fat-soluble Vitamin Deficiencies and Inflammatory Bowel Disease: Systematic Review and Meta-Analysis. J Clin Gastroenterol. 2017;51(10):878-889.
[24] Isozaki Y, Yoshida N, Kuroda M, et al. Effect of a novel water-soluble vitamin E derivative as a cure for TNBS-induced colitis in rats. Int J Mol Med. 2006;17(3):497-502.
[25] Bitiren M, Karakilcik AZ, Zerin M, et al. Protective effects of selenium and vitamin E combination on experimental colitis in blood plasma and colon of rats. Biol Trace Elem Res. 2010;136(1):87-95.
[26] Alkhouri RH, Hashmi H, Baker RD, Gelfond D, Baker SS. Vitamin and mineral status in patients with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2013;56(1):89-92.
[27] Saw TY, Malik NA, Lim KP, et al. Oral Supplementation of Tocotrienol-Rich Fraction Alleviates Severity of Ulcerative Colitis in Mice. J Nutr Sci Vitaminol (Tokyo). 2019;65(4):318-327.
[28] Kaitha S, Bashir M, Ali T. Iron deficiency anemia in inflammatory bowel disease. World J Gastrointest Pathophysiol. 2015;6(3):62-72.
[29] Nielsen OH, Ainsworth M, Coskun M, Weiss G. Management of Iron-Deficiency Anemia in Inflammatory Bowel Disease: A Systematic Review. Medicine (Baltimore). 2015;94(23):e963.
[30] Lee TW, Kolber MR, Fedorak RN, van Zanten SV. Iron replacement therapy in inflammatory bowel disease patients with iron deficiency anemia: a systematic review and meta-analysis. J Crohns Colitis. 2012;6(3):267-275.
[31] Gisbert JP, Bermejo F, Pajares R, et al. Oral and intravenous iron treatment in inflammatory bowel disease: hematological response and quality of life improvement. Inflamm Bowel Dis. 2009;15(10):1485-1491.
[32] Patel D, Trivedi C, Khan N. Management of Anemia in Patients with Inflammatory Bowel Disease (IBD). Curr Treat Options Gastroenterol. 2018;16(1):112-128.
[33] Allocca M, Fiorino G, Danese S. Iron deficiency: the hidden miscreant in inflammatory bowel disease. Curr Drug Targets. 2014;15(11):1011-1019.
[34] Ghishan FK, Kiela PR. Vitamins and Minerals in Inflammatory Bowel Disease. Gastroenterol Clin North Am. 2017;46(4):797-808.
[35] Rossi RE, Whyand T, Murray CD, Hamilton MI, Conte D, Caplin ME. The role of dietary supplements in inflammatory bowel disease: a systematic review. Eur J Gastroenterol Hepatol. 2016;28(12):1357-1364.
[36] Masri OA, Chalhoub JM, Sharara AI. Role of vitamins in gastrointestinal diseases. World J Gastroenterol. 2015;21(17):5191-5209.
[37] Bager P, Hvas CL, Rud CL, Dahlerup JF. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease. Aliment Pharmacol Ther. 2021;53(1):79-86.
[38] Costantini A, Pala MI. Thiamine and fatigue in inflammatory bowel diseases: an open-label pilot study. J Altern Complement Med. 2013;19(8):704-708.
[39] Oudman E, Wijnia JW, Oey MJ, van Dam M, Postma A. Wernicke's encephalopathy in Crohn's disease and ulcerative colitis. Nutrition. 2021;86:111182.
[40] Schäffler H, Schmidt M, Huth A, Reiner J, Glass Ä, Lamprecht G. Clinical factors are associated with vitamin D levels in IBD patients: A retrospective analysis. J Dig Dis. 2018;19(1):24-32.
[41] Frigstad SO, Høivik M, Jahnsen J, et al. Vitamin D deficiency in inflammatory bowel disease: prevalence and predictors in a Norwegian outpatient population. Scand J Gastroenterol. 2017;52(1):100-106.
[42] Li J, Chen N, Wang D, Zhang J, Gong X. Efficacy of vitamin D in treatment of inflammatory bowel disease: A meta-analysis. Medicine (Baltimore). 2018;97(46):e12662.
[43] Ulitsky A, Ananthakrishnan AN, Naik A, et al. Vitamin D deficiency in patients with inflammatory bowel disease: association with disease activity and quality of life. JPEN J Parenter Enteral Nutr. 2011;35(3):308-316.
[44] Del Pinto R, Pietropaoli D, Chandar AK, Ferri C, Cominelli F. Association Between Inflammatory Bowel Disease and Vitamin D Deficiency: A Systematic Review and Meta-analysis. Inflamm Bowel Dis. 2015;21(11):2708-2717.
[45] van der Hulst RR, von Meyenfeldt MF, Soeters PB. Glutamine: an essential amino acid for the gut. Nutrition. 1996;12(11-12 Suppl):S78-S81.
[46] Roth E, Spittler A, Oehler R. Glutamin: Wirkungen auf das Immunsystem, auf Eiweisshaushalt und Darmfunktionen [Glutamine: effects on the immune system, protein balance and intestinal functions]. Wien Klin Wochenschr. 1996;108(21):669-676.
[47] Fraga Fuentes MD, de Juana Velasco P, Pintor Recuenco R. Papel metabólico de la glutamina y su importancia en la terapia nutricional [Metabolic role of glutamine and its importance in nutritional therapy]. Nutr Hosp. 1996;11(4):215-225.
[48] van der Hulst RR, von Meyenfeldt MF, Soeters PB. Glutamine: an essential amino acid for the gut. Nutrition. 1996;12(11-12 Suppl):S78-S81.
[49] Achamrah N, Déchelotte P, Coëffier M. Glutamine and the regulation of intestinal permeability: from bench to bedside. Curr Opin Clin Nutr Metab Care. 2017;20(1):86-91.
[50] Wang B, Wu G, Zhou Z, et al. Glutamine and intestinal barrier function. Amino Acids. 2015;47(10):2143-2154.
[51] Perna S, Alalwan TA, Alaali Z, et al. The Role of Glutamine in the Complex Interaction between Gut Microbiota and Health: A Narrative Review. Int J Mol Sci. 2019;20(20):5232. Published 2019 Oct 22.
[52] Zhu A, Patel I, Hidalgo M, Gandhi V. N-Acetylglucosamine for Treatment of Inflammatory Bowel Disease. Nat. Med. J. 2015;7:2015-04.
[53] Salvatore S, Heuschkel R, Tomlin S, Davies SE, Edwards S, Walker‐Smith JA, French I, Murch SH. A pilot study of N‐acetyl glucosamine, a nutritional substrate for glycosaminoglycan synthesis, in paediatric chronic inflammatory bowel disease. Alimentary pharmacology & therapeutics. 2000 Dec 27;14(12):1567-79.
[54] Choi SI, Shin YC, Lee JS, Yoon YC, Kim JM, Sung MK. N-Acetylglucosamine and its dimer ameliorate inflammation in murine colitis by strengthening the gut barrier function. Food & Function. 2023;14(18):8533-44.
[55] Hwang C, Ross V, Mahadevan U. Micronutrient deficiencies in inflammatory bowel disease: from A to zinc. Inflammatory bowel diseases. 2012 Oct 1;18(10):1961-81.
[56] Siva S, Rubin DT, Gulotta G, Wroblewski K, Pekow J. Zinc deficiency is associated with poor clinical outcomes in patients with inflammatory bowel disease. Inflammatory Bowel Diseases. 2017 Jan 1;23(1):152-7.
[57] Ratajczak AE, Szymczak-Tomczak A, Rychter AM, Zawada A, Dobrowolska A, Krela-Kaźmierczak I. Does folic acid protect patients with inflammatory bowel disease from complications?. Nutrients. 2021 Nov 12;13(11):4036.
[58] Burr NE, Hull MA, Subramanian V. Folic acid supplementation may reduce colorectal cancer risk in patients with inflammatory bowel disease: a systematic review and meta-analysis. Journal of clinical gastroenterology. 2017 Mar 1;51(3):247-53.
[59] Barbalho SM, de Alvares Goulart R, Quesada K, Bechara MD, de Carvalho AD. Inflammatory bowel disease: can omega-3 fatty acids really help?. Annals of gastroenterology: quarterly publication of the Hellenic Society of Gastroenterology. 2016 Jan;29(1):37.
[60] Marton LT, Goulart RD, Carvalho AC, Barbalho SM. Omega fatty acids and inflammatory bowel diseases: an overview. International journal of molecular sciences. 2019 Sep 30;20(19):4851.
[61] Saibeni S, Cattaneo M, Vecchi M, Zighetti ML, Lecchi A, Lombardi R, Meucci G, Spina L, De Franchis R. Low vitamin B6 plasma levels, a risk factor for thrombosis, in inflammatory bowel disease: role of inflammation and correlation with acute phase reactants. Official journal of the American College of Gastroenterology| ACG. 2003 Jan 1;98(1):112-7.
[62] Moon N, Figgins B, Altshuler E, Pham A, Kamel AY. Concurrent zinc and vitamin B6 deficiencies in acutely exacerbated inflammatory bowel disease. Nutrition in Clinical Practice. 2022 Feb;37(1):203-8.
[63] Yakut M, Üstün Y, Kabaçam G, Soykan I. Serum vitamin B12 and folate status in patients with inflammatory bowel diseases. European journal of internal medicine. 2010 Aug 1;21(4):320-3.
[64] Headstrom PD, Rulyak SJ, Lee SD. Prevalence of and risk factors for vitamin B12 deficiency in patients with Crohn's disease. Inflammatory bowel diseases. 2008 Feb 1;14(2):217-23.
[65] Vernia P, Loizos P, Di Giuseppantonio I, Amore B, Chiappini A, Cannizzaro S. Dietary calcium intake in patients with inflammatory bowel disease. Journal of Crohn's and Colitis. 2014 Apr 1;8(4):312-7.
[66] Abitbol V, Mary JY, Roux C, Soulé JC, Belaiche J, Dupas JL, Gendre JP, Lerebours E, Chaussade S, Groupe D'etudes Thérapeutiques des Affections Inflammatoires Digestives (GETAID). Osteoporosis in inflammatory bowel disease: effect of calcium and vitamin D with or without fluoride. Alimentary pharmacology & therapeutics. 2002 May;16(5):919-27.
[67] Galland L. Magnesium and inflammatory bowel disease. Magnesium. 1988 Jan 1;7(2):78-83.
[68] Kruis W, Phuong Nguyen G. Iron deficiency, zinc, magnesium, vitamin deficiencies in Crohn's disease: substitute or not?. Digestive Diseases. 2016 Mar 16;34(1-2):105-11.
[69] Dunleavy KA, Ungaro RC, Manning L, Gold S, Novak J, Colombel JF. Vitamin C deficiency in inflammatory bowel disease: the forgotten micronutrient. Crohn's & Colitis 360. 2021 Jan 1;3(1):otab009.
[70] Gordon BL, Galati JS, Yang S, Longman RS, Lukin D, Scherl EJ, Battat R. Prevalence and factors associated with vitamin C deficiency in inflammatory bowel disease. World journal of gastroenterology. 2022 Sep 9;28(33):4834.
[71] Langmead L, Makins RJ, Rampton DS. Anti‐inflammatory effects of aloe vera gel in human colorectal mucosa in vitro. Alimentary pharmacology & therapeutics. 2004 Mar;19(5):521-7.
[72] Triantafyllidi A, Xanthos T, Papalois A, Triantafillidis JK. Herbal and plant therapy in patients with inflammatory bowel disease. Annals of gastroenterology: quarterly publication of the Hellenic Society of Gastroenterology. 2015 Apr;28(2):210.
[73] Mozaffari S, Abdollahi M. Melatonin, a promising supplement in inflammatory bowel disease: a comprehensive review of evidences. Current pharmaceutical design. 2011 Dec 1;17(38):4372-8.
[74] Vaghari-Tabari M, Moein S, Alipourian A, Qujeq D, Malakoti F, Alemi F, Yousefi B, Khazaie S. Melatonin and inflammatory bowel disease: From basic mechanisms to clinical application. Biochimie. 2023 Jun 1;209:20-36.
[75] Prakash A, Medhi B, Avti PK, Saikia UN, Pandhi P, Khanduja KL. Effect of different doses of Manuka honey in experimentally induced inflammatory bowel disease in rats. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2008 Nov;22(11):1511-9.
[76] Medhi B, Prakash A, Avti PK, Saikia UN, Pandhi P, Khanduja KL. Effect of Manuka honey and sulfasalazine in combination to promote antioxidant defense system in experimentally induced ulcerative colitis model in rats.
[77] Edwards SE, da Costa Rocha I, Williamson EM, Heinrich M. Slippery Elm Ulmus rubra Muhl.
[78] Ke F, Yadav PK, Ju LZ. Herbal medicine in the treatment of ulcerative colitis. Saudi Journal of Gastroenterology. 2012 Jan 1;18(1):3-10.
[79] Song G, Fiocchi C, Achkar JP. Acupuncture in inflammatory bowel disease. Inflammatory Bowel Diseases. 2019 Jun 18;25(7):1129-39.
[80] Liu Z, Jiao Y, Yu T, Wang H, Zhang Y, Liu D, Xu Y, Guan Q, Lu M. A review on the immunomodulatory mechanism of acupuncture in the treatment of inflammatory bowel disease. Evidence‐Based Complementary and Alternative Medicine. 2022;2022(1):8528938.
[81] Patil SS, Patil VS, Rangnekar SS. A case study: Ayurvedic management of Pravahika with special reference to inflammatory bowel disease. World Journal of Advanced Research and Reviews. 2022;14(2):322-7.
[82] Bindu KK, Menon BG. Traditional Kerala Ayurvedic formulations as a guideline for the management of Inflammatory Bowel Disease (IBD)-a review.
[83] Vasant DH, Limdi JK, Solanki K, Radhakrishnan NV. Biofeedback therapy improves continence in quiescent inflammatory bowel disease patients with anorectal dysfunction. J Gastroenterol Pancreatol Liver Disord. 2016 May 11;3:1-4.
[84] Vasant DH, Limdi JK, Solanki K, Radhakrishnan NV. PTU-121 Anorectal Dysfunction in Quiescent Inflammatory Bowel Disease: Is There A Role for Biofeedback Therapy?. Gut. 2016 Jun 1;65:A116.
[85] Szigethy E. Hypnotherapy for inflammatory bowel disease across the lifespan. American Journal of Clinical Hypnosis. 2015 Jul 10;58(1):81-99.
[86] Emami MH, Gholamrezaei A, Daneshgar H. Hypnotherapy as an adjuvant for the management of inflammatory bowel disease: a case report. American Journal of Clinical Hypnosis. 2009 Jan 1;51(3):255-62.
[87] Singh AK, Jha DK, Jena A, Kumar-M P, Sebastian S, Sharma V. Hyperbaric oxygen therapy in inflammatory bowel disease: a systematic review and meta-analysis. European Journal of Gastroenterology & Hepatology. 2021 Dec 1;33(1S):e564-73.
[88] Dawra S, Manrai M, Kumar A, Kumar S. Hyperbaric oxygen therapy in inflammatory bowel disease: a systemic review and meta-analysis. European Journal of Gastroenterology & Hepatology. 2022 Mar 1;34(3):359-60.
[89] Sienkiewicz M, Szymańska P, Fichna J. Supplementation of bovine colostrum in inflammatory bowel disease: benefits and contraindications. Advances in Nutrition. 2021 Mar 1;12(2):533-45.
[90] Chae A, Aitchison A, Day AS, Keenan JI. Bovine colostrum demonstrates anti-inflammatory and antibacterial activity in in vitro models of intestinal inflammation and infection. Journal of Functional Foods. 2017 Jan 1;28:293-8.

1. Butyrate: Butyrate, a short-chain fatty acid, plays a crucial role in regenerating the colon lining. It supports gastrointestinal function by maintaining the integrity of the intestinal barrier, promoting overall gut health.

2. Vitamin E: Vitamin E acts as a powerful antioxidant, inhibiting oxidative damage and inflammatory cytokines. Its ability to reduce colon inflammation makes it beneficial for maintaining gastrointestinal health.

3. Vitamin D3/K2: Vitamin D3 helps regulate immune responses, reducing inflammation and promoting overall gut health. Vitamin K2, when combined with D3, supports calcium metabolism and reduces inflammation in the gastrointestinal tract.

4. Omega 3: Omega-3 fatty acids are known for their anti-inflammatory properties, helping to reduce intestinal inflammation. They may decrease the severity and frequency of symptoms by modulating inflammatory responses in the gut.

5. Iron: Iron helps address anemia, a common issue due to malabsorption or blood loss, ensuring healthy red blood cell production and overall energy levels.

6. Vitamin B1 [Thiamin]: Vitamin B1 (Thiamin) supports energy metabolism and helps alleviate fatigue by promoting proper carbohydrate breakdown and energy production.

7. Glutamine: Glutamine supports the integrity of the gastrointestinal lining by protecting the mucosa, helping maintain gut health and aiding in digestive function.

8. Multivitamins: Multivitamins help address nutrient deficiencies, providing essential vitamins and minerals that support overall gut health and nutrient absorption.

9. N-Acetyl-D-Glucosamine [NAG]: N-acetyl-D-glucosamine (NAG) strengthens the intestinal barrier by supporting glycoprotein production, reducing inflammation, and promoting the repair of damaged tissues.

10. Zinc: Zinc is essential for immune function and tissue repair, promoting wound healing in the intestinal lining while regulating inflammation to support digestive health.

11. Vitamin B9 [Folate]: Folate supports DNA synthesis and cell division, both of which are critical for regenerating the gut lining and maintaining overall gut health.

12. Vitamin B6 [Pyridoxine]: Vitamin B6 aids protein metabolism and neurotransmitter production, helping regulate immune responses and reduce inflammation, while supporting red blood cell formation.

13. Vitamin B12 [Cobalamin]: Vitamin B12 is crucial for nerve function and red blood cell production. It helps prevent anemia, particularly in cases of malabsorption, and supports energy levels and cognitive function.

14. Calcium: Calcium is essential for maintaining bone density, especially when malabsorption reduces calcium absorption. It also supports muscle contraction and nerve signaling, contributing to overall health.

15. Magnesium: Magnesium aids muscle and nerve function and is crucial for energy production. It helps relieve muscle cramps and fatigue, promoting better overall health and well-being.

16. Vitamin C: Vitamin C promotes collagen synthesis and wound healing, crucial for repairing the gut lining. Its antioxidant properties help reduce inflammation and oxidative stress, supporting overall digestive health.

17. Melatonin: Melatonin’s anti-inflammatory and antioxidant effects help reduce inflammation and oxidative stress, while supporting gut healing and immune regulation.

18. Colostrum: Colostrum reduces pro-inflammatory cytokines, strengthens the gut barrier, and promotes healing by decreasing intestinal permeability and supporting tissue repair.

1. Curcumin: Curcumin strengthens the intestinal barrier by reducing bacterial movement and inflammation, promoting overall gastrointestinal health and reducing digestive discomfort.

2. Boswellia Serrata Extract: Boswellia serrata helps prevent inflammation-related damage to the intestinal lining, supporting gut health and enhancing the body's resilience to inflammation.

3. Aloe Vera Juice: Aloe vera juice, with its soothing and anti-inflammatory properties, helps reduce gut inflammation and promotes healing by calming irritated tissues and supporting digestive health.

4. Slippery Elm Extract: Slippery elm contains mucilage, a gel-like substance that coats and soothes the intestinal lining, protecting it from irritation and reducing inflammation, helping to improve gut health.

1. Manuka Honey: Manuka honey helps reduce gut inflammation, promotes tissue repair, and combats harmful bacteria, supporting digestive health and aiding in the healing of the gut lining.

1. Acupuncture: Acupuncture may reduce inflammation and pain by stimulating points associated with gastrointestinal function, such as ST36 (Zusanli) and LI11 (Quchi). This can help modulate the immune system and alleviate digestive symptoms.

2. Ayurveda: Ayurvedic treatments, including herbal remedies and lifestyle adjustments, help balance the body's energies, reduce inflammation, and promote digestive health.

3. Biofeedback: Biofeedback helps reduce stress and anxiety by teaching control over physiological responses, such as heart rate and muscle tension, improving bowel function and reducing the frequency of flare-ups.

4. Hypnotherapy: Hypnotherapy helps manage stress and pain by promoting relaxation and reducing gut inflammation, improving gastrointestinal function and alleviating discomfort.

5. Hyperbaric Chamber Therapy: Hyperbaric oxygen therapy reduces inflammation and promotes tissue healing by increasing oxygen levels in the body, supporting the repair of damaged tissues and improving gut health.

Supplements

Plant Extracts

Natural Compounds

Alternative Treatments

Symptoms & Signs

Causes

Genetic Factors, Infection, Antibiotics, Poor Diet, Poorly Functioning Immune System

Books That You May Want To Read

How Nutrients Function

Amino Acids: Amino acids serve as the building blocks of proteins, crucial for muscle growth and repair. Additionally, they play key roles in maintaining proper pH levels, storing nitrogen, synthesizing hormones, and facilitating enzymatic reactions.


Electrolytes: Electrolytes carry charged ions essential for transmitting nerve impulses, regulating muscle function, and maintaining fluid balance. They are pivotal in supporting hydration, nerve signaling, and overall physiological balance.


Fatty Acids: Fatty acids serve as energy sources, structural components of cell membranes, and precursors to signaling molecules. Essential fatty acids, like omega-3 and omega-6, play critical roles in brain function, cardiovascular health, and inflammation regulation.


Herbal Extracts: Herbal extracts contain bioactive compounds with various medicinal properties, including antioxidant, anti-inflammatory, and antimicrobial effects. They have been used traditionally to support digestion, immunity, and overall health.


Minerals: Minerals are essential for various physiological functions, including bone health, nerve transmission, and enzyme activity. They support overall health by ensuring proper cellular function and metabolic processes.


Other Nutrients: Other nutrients encompass a wide array of essential compounds crucial for various physiological functions. This category includes neurotransmitters and their precursors, which facilitate nerve signaling and are vital for central nervous system function. Additionally, naturally occurring structural components and biological detergents, such as phospholipids and bile salts, play critical roles in tissue repair, fat digestion, and overall bodily function. Phospholipids contribute to cell membrane integrity and fat emulsification, while bile salts are key to digesting and absorbing dietary fats. Hormones and their precursors regulate numerous physiological processes, including metabolism, growth, and reproduction. Furthermore, naturally occurring chemicals and metals play pivotal roles in enzymatic reactions, immune function, and overall health maintenance.


Vitamins: Vitamins are essential micronutrients that play diverse roles in supporting cellular processes, immune function, and overall health. They must be obtained through diet or supplementation to ensure proper bodily function.

Nutrients Explained In Nutritional Guide

Podcast Episodes To Listen To

Educational Videos To Learn From

Functional Lab Tests That You Might Consider

References

Things To Do

Inflammatory Bowel Disease requires dietary adjustments to manage this condition. The recommendations include:


  • a whole-foods-based diet consisting of fresh vegetables, fruits, legumes, lean meat, fish, and healthy fats.

  • maintaining a healthy omega-3 to omega-6 ratio, which ideally should be between 1:1 and 1:2.5.

  • dietary fiber intake from whole foods, such as vegetables, fruits, and legumes. It strengthens the intestinal lining, benefits the intestinal flora, and supports immune function.

  • Opt for nonacidic vegetables, either fresh, steamed, or boiled.

  • probiotic foods, such as fermented vegetables, pickles, sauerkraut, miso, tempeh, kimchi, plain yogurt, and aged cheese.

  • prebiotic foods, such as bananas, asparagus, garlic, onions, leeks, flaxseeds, chia seeds, etc.

  • Both prebiotics and probiotics will help address gut dysbiosis.

  • stay hydrated. Drink quality mineral water, herbal teas, vegetable juices, etc.

  • Eat whole foods rich in zinc, folic acid, and vitamin B12. They are essential elements that people suffering from IBD tend to be deficient in.

  • anti-inflammatory foods, such as vegetables, fruits, ginger, turmeric, garlic, onions, fatty fish, extra virgin olive oil, etc.

  • Use anti-inflammatory herbs such as black pepper, clove, fenugreek, cinnamon, oregano, thyme, cayenne pepper, etc.

  • Steaming, boiling, or baking your food are the best cooking options for IBD.

  • Prepare your meals at home. Rely on organic produce, free from pesticides, etc.

  • Incorporate soups and broths into your diet.

  • During a flare-up, consume organic baby foods. They are easy to ingest and digest.

  • Drink coffee and caffeinated teas in moderation.


Furthermore, try the following:


  • be physically active. Match the intensity of your movement with your current health condition. If you can't do any workouts, opt for walking every day. Taking a long walk in the park will not only benefit your condition, but it will also get you some fresh air, nature interaction, and sun exposure.

  • manage your pain naturally for as long as it is bearable. Use heating pads to ease the uncomfortable feeling.

  • manage your stress through yoga, mindfulness, or meditation practice.

  • get quality sleep.

  • maintain a healthy weight.

  • Exchange commercially available cleaning supplies, body care products, and make-up products for safe and toxin-free alternatives.

Things To Avoid

The following foods are not beneficial for those with IBD:


  • processed, junk, and fast foods. They contain trans fatty acids, sugar, refined carbohydrates, added salt, and food additives. All of these have a negative impact on our GI tract.

  • foods you are allergic to or intolerant of. Watch out for lactose, wheat, and high-histamine produce.

  • sugar, candy, sugary snacks and beverages, cakes, pies, muffins, and other baked goods. Sugar is very inflammatory.

  • refined carbohydrates, such as white flour, breads, pastas, pizza dough, pastries, etc.

  • trans fats found in processed foods, margarines, ready-to-eat meals, etc.

  • beer, carbonated drinks, energy drinks, sweetened fruit juices, etc.

  • greasy, deep-fired, or grilled foods, which are high in AEGs.

  • food additives, such as carrageenan, maltodextrin, polysorbate 80, and carbosymethylcellulose. They induce inflammation.

  • grains, which may be poorly tolerated.

  • dairy products, which induce mucus production and disrupt protein digestion.

  • refined seed and vegetable oils, such as canola, sunflower, safflower, rapeseed, soybean, corn, etc. These oils are inflammatory, even more so when heated.

  • takeout and restaurant food.


Additionally, watch out for the following:


  • the use of antibiotics that treat both infections and are found in non-organic meats. They damage intestinal flora and are positively associated with an increased risk of IBD symptoms.

  • insufficient sleep.

  • sedentary lifestyle and lack of physical activity.

  • being overweight and obese.

  • chronic stress.

  • undereating, which contributes to nutritional deficiencies and malnutrition.

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