Detoxing
Description
This page has 46 references
"Detoxing" is the body’s natural method of eliminating harmful substances absorbed from diet, environment, or lifestyle. The liver, kidneys, intestines, and lymphatic system work together to neutralize and expel toxins through urine, stool, sweat, and breath. When overwhelmed, the body stores toxins in fat tissue until they can be cleared. Staying hydrated, eating antioxidant-rich foods, and exercising regularly can enhance this process. Incorporating daily detox-supportive habits helps reduce toxic load and supports long-term energy and vitality.
Symptoms & Signs
Body System
Causes
Not Applicable
Things To Do
The detoxification process can be divided into three phases. Each detoxification phase can be supported by dietary modifications that deliver the necessary micronutrients. Produce and foods that we eat when detoxifying our bodies should always be organic.
In phase I, we should consume a whole-foods-based diet that includes:
variety of vegetables, including cruciferous vegetables, garlic, and onions,
fruits such as blueberries, grapes, tangerines, and oranges
fish,
lean meat,
chamomile, peppermint, green, and black teas,
Curcumin, chili powder, rosemary,
filtered or mineral water.
In phase II, we should consume a whole-foods-based diet that includes:
cruciferous vegetables, leafy green vegetables, garlic, and onions,
eggs, ghee
meat, including lean meat, beef, pork, lamb, and liver,
fruits such as grapes, strawberries, and blueberries
dandelion, rooibos, honeybush tea, water,
rosemary, Curcumin,
fermented soy.
In phase III, we should consume a whole-foods-based diet that includes:
vegetables and fruits,
plenty of mineral or filtered water and herbal tea,
meat and fish,
Curcumin, rosemary.
Furthermore, to support our system's detoxification process, we should:
follow a fasting regimen, such as intermittent fasting, time-restricted eating, etc.
get enough sleep. During sleep, our bodies perform many important functions, including detoxification.
excercise regularily
Things To Avoid
Things to avoid that interrupt the detoxification process:
the consumption of processed, packaged, and fast foods.
eating sugar, sugary snacks and desserts, and drinking sweetened beverages.
alcohol consumption.
dehydration.
caffeine in the form of coffee or caffeinated beverages.
environmental toxins. Reduce your exposure to the toxins around you. Pick natural cleaning products, body and hair care products, make-up items, etc.
exposure to pesticides, herbicides, and fungicides in fresh produce.
Furthermore, also avoid:
staying up late at night.
smoking.
stress.
drugs and medications.
physical inactivity.
long working hours.
Supplements
Direct Support
(Most Helpful → Least Helpful)
These supplements directly support detoxification by enhancing liver function, promoting toxin elimination, or binding and removing harmful substances from the body.
Gluthatione: Glutathione aids detox by neutralizing free radicals and removing heavy metals and fat-soluble toxins from the liver, kidneys, and lungs. Its antioxidant properties also support cellular detox and overall organ health.
N-Acetyl-L-Cysteine [NAC]: NAC boosts detox by increasing glutathione levels and supporting the removal of toxins from the body. Its anti-inflammatory effects and ability to break down mucus further enhance the detox process, especially in the lungs and liver.
Selenium: Selenium plays a vital role in detoxification by serving as a key component of glutathione peroxidase, an enzyme that reduces oxidative stress by breaking down harmful peroxides. It also helps bind heavy metals, such as mercury, thereby facilitating their excretion and reducing toxicity in the body.
Nattokinase: Nattokinase, a proteolytic enzyme, aids detox by breaking down accumulated proteins in the bloodstream. By improving circulation and supporting enzymatic activity, it helps the body eliminate harmful protein build-up and toxins, enhancing overall immune and circulatory health.
Serrapeptase: Serrapeptase crosses the blood-brain barrier and reduces IL-6-induced inflammation, aiding in protein toxicity and neurodegeneration. Combined with nattokinase and curcumin, it enhances detoxification and inflammation control through synergistic effects on fibrinolysis and antioxidant activity.
Indirect Support
(Most Helpful → Least Helpful)
These supplements do not detoxify directly but may support overall detox pathways by reducing inflammation, strengthening immune response, or improving gut and kidney function.
No replicated and convincing research studies are available, and there is no anecdotal evidence supporting the effectiveness of this method.
Natural Compounds
These natural compounds may aid detoxification by binding toxins, supporting metabolic clearance, or nourishing organs involved in waste elimination.
Activated Charcoal: Activated charcoal binds to toxins in the digestive tract, preventing their absorption into the bloodstream. This process supports detoxification by facilitating the elimination of harmful substances.
Zeolite: Zeolite’s porous structure traps toxins and heavy metals, helping to remove them from the body while supporting overall detoxification and health.
Bentonite Clay: Bentonite clay adsorbs toxins and impurities in the digestive tract, helping remove them through feces and supporting effective detoxification.
Plant Extracts
Direct Support
(Most Helpful → Least Helpful)
These plant extracts directly support detoxification by stimulating liver enzymes, promoting bile flow, or enhancing natural elimination processes.
Chlorella: Chlorella binds to heavy metals and other toxins in the body, helping to facilitate their removal, thereby supporting a comprehensive detoxification process.
Milk Thistle Extract: Milk thistle, rich in silymarin, protects liver cells from damage and promotes regeneration. Its antioxidant properties enhance the liver’s detoxification capacity by improving the removal of toxins and supporting overall liver health.
Dandelion Root Extract: Dandelion root stimulates bile production, which binds to fat-soluble toxins for elimination. Its natural diuretic properties increase urine output, aiding in the removal of toxins from the body.
Curcumin: Curcumin complements the action of proteolytic enzymes like nattokinase, serrapeptase, and bromelain by supporting liver detoxification. It stimulates bile production and promotes the breakdown of toxins while providing antioxidant and anti-inflammatory benefits that protect cells from oxidative stress, facilitating a comprehensive detox.
Bromelain: Bromelain is a proteolytic enzyme that enhances detox by breaking down foreign proteins and reducing inflammation throughout the body. This supports the immune system in efficiently clearing proteins and toxins, promoting a faster recovery and a more effective detox process.
Black Cumin Seed Oil: Black cumin seed oil has been shown to support detoxification by enhancing liver function and promoting antioxidant activity. It boosts the liver’s ability to neutralize toxins while reducing oxidative stress, contributing to the body’s natural detox processes.
Indirect Support
(Most Helpful → Least Helpful)
These extracts do not act directly on detoxification but may support energy, immune balance, or tissue repair that contributes to effective detox.
Green Tea Extract: Green tea, from Camellia sinensis, contains catechins like EGCG that reduce oxidative stress and support detox pathways. By indirectly enhancing enzymes such as glutathione-S-transferase (GST) and superoxide dismutase (SOD), it strengthens the body’s ability to neutralize harmful substances.
Alternative Treatments
These alternative therapies support internal detoxification, encourage natural elimination processes, and help restore systemic balance.
Coffee Enema: Coffee enema stimulates bile release from the liver and gallbladder, aiding in the digestion of fats and promoting the elimination of toxins. This process enhances detoxification and supports liver function.
Books That You May Want To Read
Podcast Episodes To Listen To
Educational Videos To Learn From
Functional Lab Tests That You Might Consider
How Key Nutrients Support the Body
Amino Acids: Amino acids serve as the building blocks of proteins, crucial for muscle growth and repair. Additionally, they play key roles in maintaining proper pH levels, storing nitrogen, synthesizing hormones, and facilitating enzymatic reactions.
Antioxidants: Antioxidants protect cells from oxidative stress caused by free radicals, potentially reducing the risk of chronic diseases such as cancer and cardiovascular ailments. They safeguard DNA integrity, slow down aging processes, and support overall cellular health.
Chelators: Chelators bind to metal ions, aiding in their removal from the body and supporting heavy metal detoxification processes. They play a vital role in mitigating the harmful effects of metal toxicity and promoting overall health.
Herbal Extracts: Herbal extracts contain bioactive compounds with various medicinal properties, including antioxidant, anti-inflammatory, and antimicrobial effects. They have been used traditionally to support digestion, immunity, and overall health.
Essential Nutrients Explained
References
[1] Mason R. Chlorella and Spirulina: Green Supplements for Balancing the Body. Alternative & Complementary Therapies. 2001, Jun.
[2] Martínez-Galero E, et al. Preclinical antitoxic properties of Spirulina (Arthrospira). Pharmaceutical Biology. 2016, 54:8, 1345-1353.
[3] Merino JJ, Parmigiani-Izquierdo JM, Toledano Gasca A, Cabaña-Muñoz ME. The Long-Term Algae Extract (Chlorella and Fucus sp) and Aminosulphurate Supplementation Modulate SOD-1 Activity and Decrease Heavy Metals (Hg++, Sn) Levels in Patients with Long-Term Dental Titanium Implants and Amalgam Fillings Restorations. Antioxidants (Basel). 2019;8(4):101.
[4] Kim YJ, Kwon S, Kim MK. Effect of Chlorella vulgaris intake on cadmium detoxification in rats fed cadmium. Nutr Res Pract. 2009;3(2):89-94.
[5] Panahi Y, Mostafazadeh B, Abrishami A, et al. Investigation of the effects of Chlorella vulgaris supplementation on the modulation of oxidative stress in apparently healthy smokers. Clin Lab. 2013;59(5-6):579-587.
[6] Queiroz MLS, et al. Chlorella vulgaris restores bone marrow cellularity and cytokine production in lead-exposed mice. Food and Chemical Toxicology. 2011, Vol49, Issue 11, pp 2934-2941.
[7] Lee I, Tran M, Evans-Nguyen T, et al. Detoxification of chlorella supplement on heterocyclic amines in Korean young adults. Environ Toxicol Pharmacol. 2015;39(1):441-446.
[8] Pizzorno J. Glutathione!. Integr Med (Encinitas). 2014;13(1):8-12.
[9] Main PA, Angley MT, O'Doherty CE, Thomas P, Fenech M. The potential role of the antioxidant and detoxification properties of glutathione in autism spectrum disorders: a systematic review and meta-analysis. Nutr Metab (Lond). 2012;9:35.
[10] Li S, et al. The role of glutathione detoxification pathway in MCLR-induced hepatotoxicity in SD rats. Environmental Toxicology. 2014, 30.
[11] Lushchak VI. Glutathione Homeostasis and Functions: Potential Targets for Medical Interventions. Journal of Amino Acids. 2012.
[12] Drisko JA. Chapter 107: Chelation Therapy.Editor(s): David Rakel. Integrative Medicine (Fourth Edition). Elsevier. 2018, Pages 1004-1015.e3.
[13] Moosavi M. Bentonite Clay as a Natural Remedy: A Brief Review. Iran J Public Health. 2017;46(9):1176-1183.
[14] Ntwampe O, Moothi K. Removal of Heavy Metals Using Bentonite Clay and Inorganic Coagulants. IntechOpen. 2018.
[15] Akpomie KG, Dawodu FA. Potential of a low-cost bentonite for heavy metal abstraction from binary component system. Beni-Suef University Journal of Basic and Applied Sciences. 2015, Vol 4, Issue 1, pp 1-13.
[16] Kraljević Pavelić S, Simović Medica J, Gumbarević D, Filošević A, Pržulj N, Pavelić K. Critical Review on Zeolite Clinoptilolite Safety and Medical Applications in vivo. Front Pharmacol. 2018;9:1350.
[17] Mastinu A, Kumar A, Maccarinelli G, et al. Zeolite Clinoptilolite: Therapeutic Virtues of an Ancient Mineral. Molecules. 2019;24(8):1517.
[18] Sahelian R. Zeolite supplement benefit and side effects, review, does it have benefits to the body? Medicina Complementar. 2014, Oct.
[19] Kraljević Pavelić S, et al. Novel, oxygenated clinoptilolite material efficiently removes aluminium from aluminium chloride-intoxicated rats in vivo. Microporous and Mesoporous Materials. 2017, Vol 249, pp 146-156.
[20] Derlet RW, Albertson TE. Activated charcoal--past, present and future. West J Med. 1986;145(4):493-496.
[21] Zellner T, Prasa D, Färber E, Hoffmann-Walbeck P, Genser D, Eyer F. The Use of Activated Charcoal to Treat Intoxications. Dtsch Arztebl Int. 2019;116(18):311-317.
[22] Neuvonen P, Olkkola K. Oral Activated Charcoal in the Treatment of Intoxications. Medical Toxicology and Adverse Drug Experience. 1998, 3.
[23] Natural Standard. Activated Charcoal: Bottom Line Monograph: A thorough review of the science behind charcoal's health benefits. Natural Medicine Journal. 2013, Vol 5, Issue 8.
[24] Lee MJ. The study of enema therapy as one of the detoxification therapy. Journal of oriental neuropsychiatry. 2004;15(2):23-36.
[25] Cha YY. A proposal of the coffee enema on obesity and metabolic syndrome. Journal of Society of Korean Medicine for Obesity Research. 2014 Dec 30;14(2):80-5.
[26] Gopalakrishnan R, Sundaram J, Sattu K, Pandi A, Thiruvengadam D. Dietary supplementation of silymarin is associated with decreased cell proliferation, increased apoptosis, and activation of detoxification system in hepatocellular carcinoma. Molecular and cellular biochemistry. 2013 May;377:163-76.
[27] Fraschini F, Demartini G, Esposti D. Pharmacology of silymarin. Clinical drug investigation. 2002 Jan;22:51-65.
[28] Kelly GS. Clinical applications of N-acetylcysteine. Alternative medicine review: a journal of clinical therapeutic. 1998 Apr 1;3(2):114-27.
[29] Raghu G, Berk M, Campochiaro PA, et al. The Multifaceted Therapeutic Role of N-Acetylcysteine (NAC) in Disorders Characterized by Oxidative Stress. Curr Neuropharmacol. 2021;19(8):1202-1224.
[30] You Y, Yoo S, Yoon HG, Park J, Lee YH, Kim S, Oh KT, Lee J, Cho HY, Jun W. In vitro and in vivo hepatoprotective effects of the aqueous extract from Taraxacum officinale (dandelion) root against alcohol-induced oxidative stress. Food and chemical toxicology. 2010 Jun 1;48(6):1632-7.
[31] Ghorbel Koubaa F, Chaâbane M, Choura B, Turki M, Makni-Ayadi F, El Feki A. Hepatoprotective effects of Taraxacum officinale root extract on permethrin-induced liver toxicity in adult mice. Pharmaceutical and Biomedical Research. 2020 Jul 10;6(3):223-36.
[32] Kyriakopoulos AM, Seneff S. Proteolytic targets for SARS-CoV-2 spike protein degradation: Hope for systemic detoxification. Journal of American Physicians and Surgeons. 2023;28(3):86-93.
[33] McCullough PA, Wynn C, Procter BC. Clinical rationale for SARS-CoV-2 base spike protein detoxification in post COVID-19 and vaccine injury syndromes. J Am Physicians Surg. 2023;28:90-3.
[34] Elbakry MM, Mansour SZ, Helal H, Ahmed ES. Nattokinase attenuates bisphenol A or gamma irradiation-mediated hepatic and neural toxicity by activation of Nrf2 and suppression of inflammatory mediators in rats. Environmental Science and Pollution Research. 2022 Oct;29(49):75086-100.
[35] Hulscher N, Procter BC, Wynn C, McCullough PA. Clinical approach to post-acute sequelae after COVID-19 infection and vaccination. Cureus. 2023 Nov;15(11).
[36] Alrawaiq NS, Abdullah A. A review of antioxidant polyphenol curcumin and its role in detoxification. Int J Pharm Tech Res. 2014;6(1):280-9.
[37] Salim EI. Cancer chemopreventive potential of volatile oil from black cumin seeds, Nigella sativa L., in a rat multi-organ carcinogenesis bioassay. Oncology letters. 2010 Sep 1;1(5):913-24.
[38] Al-Massari MH, Zeid IM, Ullah I, Alkenani NA. Effect of Nigella sativa Oil on Female Rats Exposed to Lead.
[39] Meghwal M, Goswami TK. Piper nigrum and piperine: an update. Phytotherapy Research. 2013 Aug;27(8):1121-30.
[40] Bhardwaj RK, Glaeser H, Becquemont L, Klotz U, Gupta SK, Fromm MF. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. Journal of Pharmacology and Experimental Therapeutics. 2002 Aug 1;302(2):645-50.
[41] Atal CK, Dubey RK, Singh J. Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism. Journal of Pharmacology and Experimental Therapeutics. 1985 Jan 1;232(1):258-62.
[42] Saha P, Das S. Regulation of hazardous exposure by protective exposure: modulation of phase II detoxification and lipid peroxidation by Camellia sinensis and Swertia chirata. Teratogenesis, carcinogenesis, and mutagenesis. 2003;23(S1):313-22.
[43] Fu Z, Jiang X, Li WW, Shi Y, Lai S, Zhuang J, Yao S, Liu Y, Hu J, Gao L, Xia T. Proanthocyanidin–aluminum complexes improve aluminum resistance and detoxification of Camellia sinensis. Journal of agricultural and food chemistry. 2020 Jul 17;68(30):7861-9.
[44] García-Sevillano MA, Rodríguez-Moro G, García-Barrera T, Navarro F, Gómez-Ariza JL. Biological interactions between mercury and selenium in distribution and detoxification processes in mice under controlled exposure. Effects on selenoprotein. Chemico-Biological Interactions. 2015 Mar 5;229:82-90.
[45] Luque-Garcia JL, Cabezas-Sanchez P, Anunciação DS, Camara C. Analytical and bioanalytical approaches to unravel the selenium–mercury antagonism: a review. Analytica chimica acta. 2013 Nov 1;801:1-3.
[46] Jadhav SB, Shah N, Rathi A, Rathi V, Rathi A. Serratiopeptidase: Insights into the therapeutic applications. Biotechnology Reports. 2020 Dec 1;28:e00544.