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Essential4Health

Get Healthy ~ Stay Healthy

Essential4Health

Get Healthy ~ Stay Healthy

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FLUORESCEIN BREAK-UP PATTERNS

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FBUP

Description

Fluorescein Break-Up Patterns test checks how stable your tear film is, helping diagnose dry eye syndrome or other surface conditions that affect your eyes. This test is often recommended if you’re experiencing dryness, irritation, or blurry vision. During the procedure, your doctor will apply a small amount of fluorescein dye to your eye. After you blink, a blue light is used to check how your tear film spreads and to identify any spots where it thins or breaks down. Break-up patterns can show whether your tear film is stable enough to keep your eyes moist and comfortable throughout the day. The results can help your doctor understand what’s causing your symptoms and recommend the best course of treatment. You may be advised to use artificial tears or prescription medications. Simple changes, like taking more breaks or cutting down on screen time, can also help reduce discomfort. Regular eye exams make it possible to catch these problems early, preventing irritation and keeping your vision clear. This can make everyday activities, such as reading, driving, or working, much more comfortable.

Fluorescein Break-Up Patterns test checks how stable your tear film is, helping diagnose dry eye syndrome or other surface conditions that affect your eyes. This test is often recommended if you’re experiencing dryness, irritation, or blurry vision. During the procedure, your doctor will apply a small amount of fluorescein dye to your eye. After you blink, a blue light is used to check how your tear film spreads and to identify any spots where it thins or breaks down. Break-up patterns can show whether your tear film is stable enough to keep your eyes moist and comfortable throughout the day. The results can help your doctor understand what’s causing your symptoms and recommend the best course of treatment. You may be advised to use artificial tears or prescription medications. Simple changes, like taking more breaks or cutting down on screen time, can also help reduce discomfort. Regular eye exams make it possible to catch these problems early, preventing irritation and keeping your vision clear. This can make everyday activities, such as reading, driving, or working, much more comfortable.

Procedure

Invasive

Sample Type

No biological sample is needed for this test.

Test Category

Eye Function

Procedure Category

Instill, Assess

Units

Not Applicable

Test Groups

Ophthalmological System Group: Tests within this group focus on evaluating the health and function of the eyes and visual system. These assessments provide insights into visual acuity, eye anatomy, and ocular health.

Optimal Range

For All Individuals:

  • Result: Negative: No abnormalities detected.

Normal Range

For All Individuals:

  • Result: Negative: No abnormalities detected.

Results That Differ From The Norm (Direct and Indirect Causes)

Abnormal results may indicate:


  • Computer vision syndrome (Eye discomfort related to prolonged computer use)

  • Dry eye disease (Insufficient tear production or poor tear quality)

  • Thyroid eye disease (Eye-related symptoms associated with thyroid disorders)

Key Reasons For Testing

  • Tear Film Assessment: Fluorescein break-up patterns (FBUP) evaluate tear film stability and integrity.

  • Fluorescein Staining: Dye is applied, and tear breakup is observed under cobalt blue light with a slit lamp.

  • Identification of Dysfunction: Detects tear film instability linked to dry eye disease (DED).

  • Quantification of Instability: Measures fluorescein breakup rates to diagnose and monitor DED.

  • Treatment Monitoring: Tracks changes in tear film and response to therapies like lubricating drops or anti-inflammatory medications.

Health Status Conditions It May Be Used To Assess

Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.

Some Prominent Medical Labs That May Offer This Test

Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.

References

Important Note

Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.


Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.

Disclaimer

This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.


Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.

[1] Yokoi N, Georgiev GA, Kato H, et al. Classification of fluorescein breakup patterns: A novel method of differential diagnosis for dry eye. Am J Ophthalmol. 2017;180:72-85.
[2] Nichols JJ, Mitchell GL, Zadnik K. The repeatability of fluorescein patterns with rigid contact lenses. Optom Vis Sci.2004;81(5):357-362.
[3] Kojima T, Ishida R, Dogru M, et al. A new noninvasive tear stability analysis system for the assessment of dry eyes. Invest Ophthalmol Vis Sci. 2005;46(3):887-895.
[4] King-Smith PE, Nichols JJ, Nichols KK, Fink BA, Braun RJ. Contributions of evaporation and other mechanisms to tear film thinning and break-up. Optom Vis Sci. 2008;85(8):623-630.
[5] Mizuno Y, Yokoi N, Bron AJ. Fluorescein tear film break-up time: More than meets the eye? Clin Exp Optom.2020;103(4):494-502.
[6] Ogawa Y, Dogru M, Uchino M, et al. Topical dexamethasone and fluorescein tear break-up patterns in dry eye. Acta Ophthalmol. 2015;93(7):e309-e315.
[7] Finis D, Pischel N, Schrader S, Geerling G. Evaluation of lipid layer thickness measurement of the tear film as a diagnostic tool for meibomian gland dysfunction. Cornea. 2013;32(12):1549-1553.
[8] Cho P, Woo WW, Chui HY, Kwan MK. Repeatability of the tear break-up time test using a fluorescein pen. Cornea.2004;23(3):286-289.
[9] Dogru M, Kojima T, Ishida R, et al. TFBUT pattern analysis using a new dry eye monitor in aqueous-deficient vs. evaporative dry eye. Invest Ophthalmol Vis Sci. 2013;54(3):2541-2550.
[10] Craig JP, Nichols KK, Akpek EK, et al. TFOS DEWS II definition and classification report. Ocul Surf.2017;15(3):276-283.
[11] Hirohara Y, Mihashi T, Tokoro T. Assessment of tear film stability in dry eye by extrapolation method with fluorescein break-up time. Nippon Ganka Gakkai Zasshi. 1996;100(3):243-248.
[12] Himebaugh NL, Begley CG, Bradley A, Wilkinson JA, Liu H. Blinking and tear break-up patterns in soft contact lens wearers. Optom Vis Sci. 2009;86(5).

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