"When Antibiotics Don’t Work" explores the alarming rise of antibiotic-resistant bacteria and poses the critical question: has the age of antibiotics come to an end? This gripping documentary follows the harrowing journey of a young girl on life support in Arizona, illustrating the urgent challenges faced by modern medicine. As her story unfolds, FRONTLINE investigates a deadly strain of bacteria that current antibiotics cannot combat, culminating in an uncontrollable outbreak at one of the nation’s most prestigious hospitals in 20XX. Through compelling storytelling and expert insights, the documentary reveals the broader implications of antibiotic overuse and the healthcare crisis of untreatable infections. Correspondent David Hoffman delves into the struggles of pharmaceutical companies to develop new antibiotics, highlighting the significant scientific and financial hurdles they face. With the drug pipeline running dry, "When Antibiotics Don’t Work" underscores the urgent need for innovative solutions to this growing public health threat.