"When Antibiotics Don’t Work" from Frontline PBS exposes the growing danger of antibiotic resistance and the collapse of modern infection treatment. Through one girl’s life-threatening case and a hospital-wide outbreak, the film underscores how overuse of antibiotics breeds untreatable bacteria. Experts and pharma leaders highlight the drying drug pipeline and regulatory challenges. This sobering and urgent documentary calls for innovation, public awareness, and responsible medical use to prevent a future where simple infections become deadly again.